Seroatlas · Human Serome Atlas

RNF14

E3 ubiquitin-protein ligase RNF14

Also known as: ARA54, HFB30, RNF14_HUMAN, TRIAD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBS8
Gene
RNF14
Ensembl
ENSG00000013561
Chromosome
5
Canonical length
474 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q9UBS8|RNF14
     1  MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN
    61  SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS
   121  VVLFAWMQFL KEETLAYLNI VSPFELKIGS QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE
   181  EIVDERAVQD VESLSNLIQE ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH
   241  VYCKACLKDY FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL
   301  DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC KVTAEKLMDL
   361  RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN SKSCPCCGTP IEKLDGCNKM
   421  TCTGCMQYFC WICMGSLSRA NPYKHFNDPG SPCFNRLFYA VDVDDDIWED EVED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 98 nTPM
  • tongue: 80 nTPM
  • testis: 70 nTPM
  • heart muscle: 67 nTPM
  • liver: 63 nTPM
  • skeletal muscle: 63 nTPM

Single-cell type

  • early spermatids: 308 nCPM
  • late primary spermatocytes: 196 nCPM
  • parietal cells: 117 nCPM
  • syncytiotrophoblasts: 104 nCPM
  • sertoli cells: 65 nCPM
  • kupffer cells: 57 nCPM

Immune cell

  • basophil: 80 nTPM
  • non-classical monocyte: 34 nTPM
  • NK-cell: 30 nTPM
  • T-reg: 29 nTPM
  • plasmacytoid DC: 29 nTPM
  • myeloid DC: 28 nTPM

Brain region

  • midbrain: 71 nTPM
  • pons: 67 nTPM
  • thalamus: 66 nTPM
  • hypothalamus: 64 nTPM
  • medulla oblongata: 64 nTPM
  • spinal cord: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
1.38
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF14 as an antibody target. Whether an autoantibody or antibody against RNF14 could matter depends on whether native RNF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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