Seroatlas · Human Serome Atlas

RNF181

E3 ubiquitin-protein ligase RNF181

Also known as: HSPC238, RN181_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0P0
Gene: RNF181
Ensembl: ENSG00000168894
Chromosome: 2
Canonical length: 153 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q9P0P0|RNF181
     1  MASYFDEHDC EPSDPEQETR TNMLLELARS LFNRMDFEDL GLVVDWDHHL PPPAAKTVVE
    61  NLPRTVIRGS QAELKCPVCL LEFEEEETAI EMPCHHLFHS SCILPWLSKT NSCPLCRYEL
   121  PTDDDTYEEH RRDKARKQQQ QHRLENLHGA MYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF181 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 129 nTPM

Expression across tissuesHPA

Tissue

liver: 129 nTPM
skeletal muscle: 125 nTPM
kidney: 124 nTPM
pancreas: 123 nTPM
choroid plexus: 110 nTPM
heart muscle: 102 nTPM

Single-cell type

esophageal apical cells: 679 nCPM
early spermatids: 395 nCPM
late primary spermatocytes: 376 nCPM
esophageal suprabasal cells: 351 nCPM
late spermatids: 345 nCPM
extravillous trophoblasts: 342 nCPM

Immune cell

total PBMC: 439 nTPM
classical monocyte: 420 nTPM
plasmacytoid DC: 361 nTPM
neutrophil: 359 nTPM
eosinophil: 341 nTPM
intermediate monocyte: 327 nTPM

Brain region

white matter: 66 nTPM
thalamus: 62 nTPM
spinal cord: 58 nTPM
hypothalamus: 58 nTPM
medulla oblongata: 57 nTPM
cerebellum: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF181 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF181 as an antibody target. Whether an autoantibody or antibody against RNF181 could matter depends on whether native RNF181 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF181 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF181 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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