Seroatlas · Human Serome Atlas

ZSWIM2

E3 ubiquitin-protein ligase ZSWIM2

Also known as: MEX, MGC33890, ZSWM2_HUMAN, ZZZ2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEG5
Gene: ZSWIM2
Ensembl: ENSG00000163012
Chromosome: 2
Canonical length: 633 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in apoptotic process and protein polyubiquitination. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q8NEG5|ZSWIM2
     1  MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE YMDFRVFLGN
    61  PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG LGEREISDLL RGIHRVQTPQ
   121  PGTNDENEHV EEDGYIKQKE IDSEDICSIC QELLLEKKLP VTFCRFGCGN SIHIKCMKIL
   181  ANYQSTSNTS MLKCPLCRKE FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF
   241  PIEGKCYKCT ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN
   301  EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA FHLGQHTRLL
   361  PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV NGQAHQSVSN RDIIHLSKQK
   421  EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD ELNTPQSPKD AYENTTIDNL CSIKLDNSNS
   481  KKLTYDYKIS QHFPRYLQDL PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS
   541  LSRMTKGCKC NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE
   601  ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

testis: 8.7 nTPM
pituitary gland: 0.6 nTPM
hypothalamus: 0.2 nTPM
basal ganglia: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 76 nCPM
early spermatids: 62 nCPM
late spermatids: 24 nCPM
somatotrophs: 10 nCPM
ependymal cells: 8.7 nCPM
thyrotrophs: 7.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.6 nTPM
medulla oblongata: 0.4 nTPM
midbrain: 0.4 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSWIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBE2D1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM2 as an antibody target. Whether an autoantibody or antibody against ZSWIM2 could matter depends on whether native ZSWIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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