Seroatlas · Human Serome Atlas

RNF182

E3 ubiquitin-protein ligase RNF182

Also known as: MGC33993, RN182_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6D2
Gene: RNF182
Ensembl: ENSG00000180537
Chromosome: 6
Canonical length: 247 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q8N6D2|RNF182
     1  MASQPPEDTA ESQASDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK IIDFGDSPQG
    61  VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGGKGKKC LPENPTELLL TPKRLASLVS
   121  PSHTSSNCLV ITIMEVQRES SPSLSSTPVV EFYRPASFDS VTTVSHNWTV WNCTSLLFQT
   181  SIRVLVWLLG LLYFSSLPLG IYLLVSKKVT LGVVFVSLVP SSLVILMVYG FCQCVCHEFL
   241  DCMAPPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF182 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 16 nTPM
cerebellum: 13 nTPM
hippocampal formation: 9.6 nTPM
retina: 8.1 nTPM
bone marrow: 8 nTPM
amygdala: 6.7 nTPM

Single-cell type

bergmann glia: 232 nCPM
astrocytes: 97 nCPM
choroid plexus epithelial cells: 65 nCPM
thyrotrophs: 51 nCPM
somatotrophs: 50 nCPM
retinal bipolar cells: 46 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 49 nTPM
cerebellum: 44 nTPM
midbrain: 34 nTPM
hippocampal formation: 34 nTPM
medulla oblongata: 33 nTPM
cerebral cortex: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, RING-type, conserved site
E3 ubiquitin-protein ligase RNF182
E3 ubiquitin-protein ligase RNF182, RING finger, HC subclass

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF182 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF182 as an antibody target. Whether an autoantibody or antibody against RNF182 could matter depends on whether native RNF182 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF182 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF182 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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