Seroatlas · Human Serome Atlas

HGS

Hepatocyte growth factor-regulated tyrosine kinase substrate

Also known as: HGS_HUMAN, Hrs, Vps27, ZFYVE8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14964
Gene
HGS
Ensembl
ENSG00000185359
Chromosome
17
Canonical length
777 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endosomes,Lysosomes,Cytosol

OverviewNCBI Gene

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>O14964|HGS
     1  MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV
    61  ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR
   121  NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVMTRKH
   181  HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS
   241  PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS
   301  APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ
   361  PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE SEESHEQFLK ALQNAVTTFV
   421  NRMKSNHMRG RSITNDSAVL SLFQSINGMH PQLLELLNQL DERRLYYEGL QDKLAQIRDA
   481  RGALSALREE HREKLRRAAE EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE
   541  KERQMRLEQQ KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE
   601  GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA QAGPTASPAY
   661  SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ SVSMGYQPYN MQNLMTTLPS
   721  QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ QQPPVAQQPQ AQGPPAQGSE AQLISFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HGS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 97 nTPM
  • cerebral cortex: 92 nTPM
  • testis: 90 nTPM
  • hippocampal formation: 89 nTPM
  • amygdala: 87 nTPM
  • midbrain: 82 nTPM

Single-cell type

  • late spermatids: 231 nCPM
  • cardiomyocytes: 160 nCPM
  • esophageal apical cells: 102 nCPM
  • esophageal suprabasal cells: 79 nCPM
  • endometrial glandular cells: 75 nCPM
  • early spermatids: 70 nCPM

Immune cell

  • basophil: 49 nTPM
  • neutrophil: 46 nTPM
  • eosinophil: 39 nTPM
  • total PBMC: 36 nTPM
  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 33 nTPM

Brain region

  • medulla oblongata: 62 nTPM
  • cerebral cortex: 60 nTPM
  • pons: 59 nTPM
  • midbrain: 57 nTPM
  • thalamus: 56 nTPM
  • white matter: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.01
gnomAD missense Z
1.28
DepMap mean gene effect
-0.71
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HGS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HGS as an antibody target. Whether an autoantibody or antibody against HGS could matter depends on whether native HGS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HGS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HGS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HGS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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