Seroatlas · Human Serome Atlas

ZFAND5

AN1-type zinc finger protein 5

Also known as: ZA20D2, ZFAN5_HUMAN, ZFAND5A, ZNF216

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76080
Gene: ZFAND5
Ensembl: ENSG00000107372
Chromosome: 9
Canonical length: 213 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>O76080|ZFAND5
     1  MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT
    61  SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITTPKTEVS
   121  EPVVTQPSPS VSQPSTSQSE EKAPELPKPK KNRCFMCRKK VGLTGFDCRC GNLFCGLHRY
   181  SDKHNCPYDY KAEAAAKIRK ENPVVVAEKI QRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 561 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 561 nTPM
adipose tissue: 293 nTPM
blood vessel: 266 nTPM
tongue: 256 nTPM
ovary: 235 nTPM
liver: 191 nTPM

Single-cell type

epididymal basal cells: 1,214 nCPM
esophageal apical cells: 967 nCPM
thymic myoid cells: 771 nCPM
ocular epithelial cells: 653 nCPM
neutrophils: 644 nCPM
endometrial glandular cells: 627 nCPM

Immune cell

non-classical monocyte: 82 nTPM
intermediate monocyte: 52 nTPM
basophil: 39 nTPM
eosinophil: 37 nTPM
classical monocyte: 36 nTPM
myeloid DC: 34 nTPM

Brain region

midbrain: 171 nTPM
basal ganglia: 166 nTPM
hypothalamus: 160 nTPM
white matter: 159 nTPM
thalamus: 156 nTPM
pons: 155 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFAND5.

Disease | ImmuneIEDB

Conditions an epitope on ZFAND5 was assayed in.

chronic lymphocytic leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.85
gnomAD missense Z: 1.44
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFAND5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND5 as an antibody target. Whether an autoantibody or antibody against ZFAND5 could matter depends on whether native ZFAND5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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