Seroatlas · Human Serome Atlas

UBAC1

Ubiquitin-associated domain-containing protein 1

Also known as: GBDR1, KPC2, UBAC1_HUMAN, UBADC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSL1
Gene
UBAC1
Ensembl
ENSG00000130560
Chromosome
9
Canonical length
405 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Involved in protein maturation and protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>Q9BSL1|UBAC1
     1  MFVQEEKIFA GKVLRLHICA SDGAEWLEEA TEDTSVEKLK ERCLKHCAHG SLEDPKSITH
    61  HKLIHAASER VLSDARTILE ENIQDQDVLL LIKKRAPSPL PKMADVSAEE KKKQDQKAPD
   121  KEAILRATAN LPSYNMDRAA VQTNMRDFQT ELRKILVSLI EVAQKLLALN PDAVELFKKA
   181  NAMLDEDEDE RVDEAALRQL TEMGFPENRA TKALQLNHMS VPQAMEWLIE HAEDPTIDTP
   241  LPGQAPPEAE GATAAASEAA AGASATDEEA RDELTEIFKK IRRKREFRAD ARAVISLMEM
   301  GFDEKEVIDA LRVNNNQQNA ACEWLLGDRK PSPEELDKGI DPDSPLFQAI LDNPVVQLGL
   361  TNPKTLLAFE DMLENPLNST QWMNDPETGP VMLQISRIFQ TLNRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
291 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 291 nTPM
  • tongue: 160 nTPM
  • bone marrow: 78 nTPM
  • heart muscle: 69 nTPM
  • skin: 51 nTPM
  • basal ganglia: 47 nTPM

Single-cell type

  • thymic myoid cells: 408 nCPM
  • erythrocyte progenitors: 374 nCPM
  • late spermatids: 341 nCPM
  • respiratory ciliated cells: 236 nCPM
  • cytotrophoblasts: 192 nCPM
  • myonuclei: 158 nCPM

Immune cell

  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 28 nTPM
  • classical monocyte: 18 nTPM
  • myeloid DC: 16 nTPM
  • eosinophil: 8.8 nTPM
  • total PBMC: 7 nTPM

Brain region

  • basal ganglia: 44 nTPM
  • thalamus: 44 nTPM
  • spinal cord: 43 nTPM
  • medulla oblongata: 41 nTPM
  • cerebellum: 41 nTPM
  • midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBAC1 as an antibody target. Whether an autoantibody or antibody against UBAC1 could matter depends on whether native UBAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBAC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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