Seroatlas · Human Serome Atlas

YOD1

Ubiquitin thioesterase OTU1

Also known as: DKFZp451J1719, DUBA8, OTU1_HUMAN, OTUD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VVQ6
Gene
YOD1
Ensembl
ENSG00000180667
Chromosome
1
Canonical length
348 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q5VVQ6|YOD1
     1  MFGPAKGRHF GVHPAPGFPG GVSQQAAGTK AGPAGAWPVG SRTDTMWRLR CKAKDGTHVL
    61  QGLSSRTRVR ELQGQIAAIT GIAPGGQRIL VGYPPECLDL SNGDTILEDL PIQSGDMLII
   121  EEDQTRPRSS PAFTKRGASS YVRETLPVLT RTVVPADNSC LFTSVYYVVE GGVLNPACAP
   181  EMRRLIAQIV ASDPDFYSEA ILGKTNQEYC DWIKRDDTWG GAIEISILSK FYQCEICVVD
   241  TQTVRIDRFG EDAGYTKRVL LIYDGIHYDP LQRNFPDPDT PPLTIFSSND DIVLVQALEL
   301  ADEARRRRQF TDVNRFTLRC MVCQKGLTGQ AEAREHAKET GHTNFGEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 55 nTPM
  • esophagus: 23 nTPM
  • skin: 15 nTPM
  • vagina: 10 nTPM
  • cervix: 9.9 nTPM
  • thymus: 9.2 nTPM

Single-cell type

  • esophageal apical cells: 612 nCPM
  • endometrial glandular cells: 171 nCPM
  • late spermatids: 171 nCPM
  • erythrocytes: 165 nCPM
  • platelets: 123 nCPM
  • endometrial luminal cells: 97 nCPM

Immune cell

  • basophil: 1 nTPM
  • neutrophil: 0.7 nTPM
  • eosinophil: 0.5 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.3 nTPM

Brain region

  • white matter: 21 nTPM
  • medulla oblongata: 13 nTPM
  • cerebral cortex: 13 nTPM
  • thalamus: 12 nTPM
  • choroid plexus: 9.7 nTPM
  • hippocampal formation: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.13
gnomAD missense Z
0.52
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YOD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YOD1 as an antibody target. Whether an autoantibody or antibody against YOD1 could matter depends on whether native YOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YOD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YOD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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