Seroatlas · Human Serome Atlas

GGA3

ADP-ribosylation factor-binding protein GGA3

Also known as: GGA3_HUMAN, KIAA0154

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ52
Gene
GGA3
Ensembl
ENSG00000125447
Chromosome
17
Canonical length
723 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>Q9NZ52|GGA3
     1  MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW
    61  EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS
   121  WTMALPEEAK IKDAYHMLKR QGIVQSDPPI PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK
   181  LLKSKNPDDL QEANKLIKSM VKEDEARIQK VTKRLHTLEE VNNNVRLLSE MLLHYSQEDS
   241  SDGDRELMKE LFDQCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ
   301  VINGEVATLT LPDSEGNSQC SNQGTLIDLA ELDTTNSLSS VLAPAPTPPS SGIPILPPPP
   361  QASGPPRSRS SSQAEATLGP SSTSNALSWL DEELLCLGLA DPAPNVPPKE SAGNSQWHLL
   421  QREQSDLDFF SPRPGTAACG ASDAPLLQPS APSSSSSQAP LPPPFPAPVV PASVPAPSAG
   481  SSLFSTGVAP ALAPKVEPAV PGHHGLALGN SALHHLDALD QLLEEAKVTS GLVKPTTSPL
   541  IPTTTPARPL LPFSTGPGSP LFQPLSFQSQ GSPPKGPELS LASIHVPLES IKPSSALPVT
   601  AYDKNGFRIL FHFAKECPPG RPDVLVVVVS MLNTAPLPVK SIVLQAAVPK SMKVKLQPPS
   661  GTELSPFSPI QPPAAITQVM LLANPLKEKV RLRYKLTFAL GEQLSTEVGE VDQFPPVEQW
   721  GNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 20 nTPM
  • tonsil: 18 nTPM
  • lymph node: 16 nTPM
  • spleen: 16 nTPM
  • esophagus: 15 nTPM
  • bone marrow: 15 nTPM

Single-cell type

  • cardiomyocytes: 153 nCPM
  • tuft cells: 81 nCPM
  • neutrophil progenitors: 72 nCPM
  • neutrophils: 69 nCPM
  • early spermatids: 52 nCPM
  • microglia: 51 nCPM

Immune cell

  • NK-cell: 8.4 nTPM
  • neutrophil: 7.3 nTPM
  • classical monocyte: 6.8 nTPM
  • plasmacytoid DC: 6.6 nTPM
  • myeloid DC: 6.4 nTPM
  • total PBMC: 6 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • white matter: 19 nTPM
  • amygdala: 18 nTPM
  • medulla oblongata: 18 nTPM
  • basal ganglia: 16 nTPM
  • thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGA3 as an antibody target. Whether an autoantibody or antibody against GGA3 could matter depends on whether native GGA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GGA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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