Seroatlas · Human Serome Atlas

GGA1

ADP-ribosylation factor-binding protein GGA1

Also known as: GGA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJY5
Gene: GGA1
Ensembl: ENSG00000100083
Chromosome: 22
Canonical length: 639 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q9UJY5|GGA1
     1  MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE
    61  WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY
   121  SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR
   181  LLKSSHPEDL RAANKLIKEM VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA
   241  AAGSSEDLMK ELYQRCERMR PTLFRLASDT EDNDEALAEI LQANDNLTQV INLYKQLVRG
   301  EEVNGDATAG SIPGSTSALL DLSGLDLPPA GTTYPAMPTR PGEQASPEQP SASVSLLDDE
   361  LMSLGLSDPT PPSGPSLDGT GWNSFQSSDA TEPPAPALAQ APSMESRPPA QTSLPASSGL
   421  DDLDLLGKTL LQQSLPPESQ QVRWEKQQPT PRLTLRDLQN KSSSCSSPSS SATSLLHTVS
   481  PEPPRPPQQP VPTELSLASI TVPLESIKPS NILPVTVYDQ HGFRILFHFA RDPLPGRSDV
   541  LVVVVSMLST APQPIRNIVF QSAVPKVMKV KLQPPSGTEL PAFNPIVHPS AITQVLLLAN
   601  PQKEKVRLRY KLTFTMGDQT YNEMGDVDQF PPPETWGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 177 nTPM

Expression across tissuesHPA

Tissue

testis: 177 nTPM
spleen: 56 nTPM
cerebellum: 55 nTPM
pituitary gland: 52 nTPM
adrenal gland: 49 nTPM
kidney: 47 nTPM

Single-cell type

late spermatids: 305 nCPM
late primary spermatocytes: 239 nCPM
early primary spermatocytes: 171 nCPM
sertoli cells: 146 nCPM
esophageal apical cells: 141 nCPM
early spermatids: 137 nCPM

Immune cell

memory CD8 T-cell: 23 nTPM
MAIT T-cell: 22 nTPM
gdT-cell: 18 nTPM
naive CD8 T-cell: 17 nTPM
NK-cell: 12 nTPM
total PBMC: 12 nTPM

Brain region

white matter: 63 nTPM
medulla oblongata: 57 nTPM
choroid plexus: 56 nTPM
thalamus: 56 nTPM
cerebral cortex: 53 nTPM
basal ganglia: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGA1 as an antibody target. Whether an autoantibody or antibody against GGA1 could matter depends on whether native GGA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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