Ubiquitin and ubiquitin-like

Definition

The ubiquitin family is characterised by its role in post-translational modification, where ubiquitin or ubiquitin-like proteins are covalently attached to target proteins, influencing their stability, localization, or activity. Ubiquitination involves the conjugation of ubiquitin to lysine residues on substrates through an isopeptide bond, often leading to proteasomal degradation. However, ubiquitin also participates in non-proteolytic functions such as DNA repair, cell cycle regulation, endocytosis, and signal transduction [[cite:PMID:16543144], [cite:PMID:34239127]]. Polyubiquitin chains linked through different lysine residues or linearly through the N-terminal methionine can have distinct cellular roles. Some family members are involved in ribosome biogenesis as fusion proteins with ribosomal proteins, contributing to the structure and function of ribosomes. The family includes ubiquitin-like modifiers such as NEDD8, which regulate cell cycle and embryogenesis by modifying cullins and other proteins to alter E3 ligase activity PMID:38605244.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• NEDD8
• RPS27A
• UBA52
• UBB
• UBC