UBE2G2

Protein identityUniProt · HPA

UniProt accession

P60604

Gene

UBE2G2

Ensembl

ENSG00000184787

Chromosome

21

Canonical length

165 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P60604|UBE2G2
     1  MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF
    61  PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL
   121  LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2G2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

65 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.86

gnomAD pLI

0.1

gnomAD missense Z

1.8

DepMap mean gene effect

-0.28

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to interferon-beta
• ERAD pathway
• negative regulation of retrograde protein transport, ER to cytosol
• protein K48-linked ubiquitination
• protein polyubiquitination
• ubiquitin-dependent protein catabolic process

Molecular functions

• ATP binding
• identical protein binding
• ubiquitin conjugating enzyme activity
• ubiquitin-protein transferase activity

Cellular components

• cytosol
• endoplasmic reticulum
• lipid droplet

Protein domainsUniProt · Pfam · InterPro

• Ubiquitin-conjugating (UBC), catalytic core domain
• Ubiquitin-conjugating enzyme/RWD-like
• Ubiquitin-conjugating enzyme, active site
• Ubiquitin-conjugating enzyme E2-like
• Ubiquitin-conjugating enzyme

KeywordsUniProt

• Acetylation
• ATP-binding
• Endoplasmic reticulum
• Lipid droplet
• Nucleotide-binding
• Transferase
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of UBE2G2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AUP1
• AMFR
• RNF139
• UBC