Seroatlas · Human Serome Atlas

SH3KBP1

SH3 domain-containing kinase-binding protein 1

Also known as: CIN85, SH3K1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96B97
Gene
SH3KBP1
Ensembl
ENSG00000147010
Chromosome
X
Canonical length
665 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q96B97|SH3KBP1
     1  MVEAIVEFDY QAQHDDELTI SVGEIITNIR KEDGGWWEGQ INGRRGLFPD NFVREIKKEM
    61  KKDPLTNKAP EKPLHEVPSG NSLLSSETIL RTNKRGERRR RRCQVAFSYL PQNDDELELK
   121  VGDIIEVVGE VEEGWWEGVL NGKTGMFPSN FIKELSGESD ELGISQDEQL SKSSLRETTG
   181  SESDGGDSSS TKSEGANGTV ATAAIQPKKV KGVGFGDIFK DKPIKLRPRS IEVENDFLPV
   241  EKTIGKKLPA TTATPDSSKT EMDSRTKSKD YCKVIFPYEA QNDDELTIKE GDIVTLINKD
   301  CIDVGWWEGE LNGRRGVFPD NFVKLLPPDF EKEGNRPKKP PPPSAPVIKQ GAGTTERKHE
   361  IKKIPPERPE MLPNRTEEKE RPEREPKLDL QKPSVPAIPP KKPRPPKTNS LSRPGALPPR
   421  RPERPVGPLT HTRGDSPKID LAGSSLSGIL DKDLSDRSND IDLEGFDSVV SSTEKLSHPT
   481  TSRPKATGRR PPSQSLTSSS LSSPDIFDSP SPEEDKEEHI SLAHRGVDAS KKTSKTVTIS
   541  QVSDNKASLP PKPGTMAAGG GGPAPLSSAA PSPLSSSLGT AGHRANSPSL FGTEGKPKME
   601  PAASSQAAVE ELRTQVRELR SIIETMKDQQ KREIKQLLSE LDEEKKIRLR LQMEVNDIKK
   661  ALQSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3KBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 58 nTPM
  • lymph node: 57 nTPM
  • bone marrow: 50 nTPM
  • thymus: 44 nTPM
  • appendix: 41 nTPM
  • adipose tissue: 38 nTPM

Single-cell type

  • neutrophils: 1,676 nCPM
  • neutrophil progenitors: 865 nCPM
  • microglia: 651 nCPM
  • choroid plexus epithelial cells: 587 nCPM
  • monocyte progenitors: 490 nCPM
  • t-cells: 466 nCPM

Immune cell

  • T-reg: 153 nTPM
  • memory CD8 T-cell: 131 nTPM
  • total PBMC: 128 nTPM
  • memory CD4 T-cell: 118 nTPM
  • gdT-cell: 117 nTPM
  • neutrophil: 117 nTPM

Brain region

  • choroid plexus: 73 nTPM
  • white matter: 38 nTPM
  • midbrain: 32 nTPM
  • thalamus: 31 nTPM
  • medulla oblongata: 31 nTPM
  • hypothalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SH3KBP1.

Disease | AllUniProt

Conditions SH3KBP1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.05
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3KBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3KBP1 as an antibody target. Whether an autoantibody or antibody against SH3KBP1 could matter depends on whether native SH3KBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3KBP1 is annotated at the cell surface, where native SH3KBP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SH3KBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3KBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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