Seroatlas · Human Serome Atlas

UBASH3B

Ubiquitin-associated and SH3 domain-containing protein B

Also known as: KIAA1959, STS-1, TULA-2, TULA2, UBS3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF42
Gene: UBASH3B
Ensembl: ENSG00000154127
Chromosome: 11
Canonical length: 649 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>Q8TF42|UBASH3B
     1  MAQYGHPSPL GMAAREELYS KVTPRRNRQQ RPGTIKHGSA LDVLLSMGFP RARAQKALAS
    61  TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL AQKLSDFWQQ SKQICGKNKA
   121  HNIFPHITLC QFFMCEDSKV DALGEALQTT VSRWKCKFSA PLPLELYTSS NFIGLFVKED
   181  SAEVLKKFAA DFAAEAASKT EVHVEPHKKQ LHVTLAYHFQ ASHLPTLEKL AQNIDVKLGC
   241  DWVATIFSRD IRFANHETLQ VIYPYTPQND DELELVPGDF IFMSPMEQTS TSEGWIYGTS
   301  LTTGCSGLLP ENYITKADEC STWIFHGSYS ILNTSSSNSL TFGDGVLERR PYEDQGLGET
   361  TPLTIICQPM QPLRVNSQPG PQKRCLFVCR HGERMDVVFG KYWLSQCFDA KGRYIRTNLN
   421  MPHSLPQRSG GFRDYEKDAP ITVFGCMQAR LVGEALLESN TIIDHVYCSP SLRCVQTAHN
   481  ILKGLQQENH LKIRVEPGLF EWTKWVAGST LPAWIPPSEL AAANLSVDTT YRPHIPISKL
   541  VVSESYDTYI SRSFQVTKEI ISECKSKGNN ILIVAHASSL EACTCQLQGL SPQNSKDFVQ
   601  MVRKIPYLGF CSCEELGETG IWQLTDPPIL PLTHGPTGGF NWRETLLQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBASH3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 21 nTPM
spleen: 15 nTPM
thymus: 14 nTPM
placenta: 13 nTPM
bone marrow: 6.3 nTPM
lymph node: 5.4 nTPM

Single-cell type

thymocytes: 817 nCPM
extravillous trophoblasts: 341 nCPM
neutrophils: 321 nCPM
syncytiotrophoblasts: 304 nCPM
hematopoietic stem cells: 281 nCPM
cytotrophoblasts: 269 nCPM

Immune cell

non-classical monocyte: 11 nTPM
eosinophil: 9.9 nTPM
NK-cell: 6.4 nTPM
intermediate monocyte: 6.3 nTPM
T-reg: 4.7 nTPM
neutrophil: 2.7 nTPM

Brain region

cerebellum: 32 nTPM
pons: 22 nTPM
medulla oblongata: 17 nTPM
midbrain: 16 nTPM
hypothalamus: 13 nTPM
thalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBASH3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBASH3B as an antibody target. Whether an autoantibody or antibody against UBASH3B could matter depends on whether native UBASH3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBASH3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBASH3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...