Seroatlas · Human Serome Atlas

DESI1

Desumoylating isopeptidase 1

Also known as: D15Wsu75e, DESI-1, DESI1_HUMAN, FAM152B, POST, PPPDE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICB0
Gene: DESI1
Ensembl: ENSG00000100418
Chromosome: 22
Canonical length: 168 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytokinetic bridge,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables importin-alpha family protein binding activity and long-chain fatty acyl-CoA hydrolase activity. Involved in protein export from nucleus and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>Q6ICB0|DESI1
     1  MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF GSGGISSCPP
    61  GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA YNLFEHNCNT FSNEVAQFLT
   121  GRKIPSYITD LPSEVLSTPF GQALRPLLDS IQIQPPGGSS VGRPNGQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DESI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

liver: 46 nTPM
heart muscle: 37 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 30 nTPM
hippocampal formation: 30 nTPM
amygdala: 29 nTPM

Single-cell type

early spermatids: 936 nCPM
late spermatids: 810 nCPM
esophageal apical cells: 585 nCPM
late primary spermatocytes: 444 nCPM
esophageal suprabasal cells: 226 nCPM
syncytiotrophoblasts: 107 nCPM

Immune cell

intermediate monocyte: 8.9 nTPM
basophil: 8.8 nTPM
eosinophil: 7.8 nTPM
classical monocyte: 6.5 nTPM
non-classical monocyte: 6.1 nTPM
myeloid DC: 5.2 nTPM

Brain region

thalamus: 50 nTPM
midbrain: 47 nTPM
hypothalamus: 47 nTPM
cerebellum: 46 nTPM
medulla oblongata: 44 nTPM
basal ganglia: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0.01
gnomAD missense Z: 0.86
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DESI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DESI1 as an antibody target. Whether an autoantibody or antibody against DESI1 could matter depends on whether native DESI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DESI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DESI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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