Seroatlas · Human Serome Atlas

GGA2

ADP-ribosylation factor-binding protein GGA2

Also known as: GGA2_HUMAN, KIAA1080, VEAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJY4
Gene
GGA2
Ensembl
ENSG00000103365
Chromosome
16
Canonical length
613 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q9UJY4|GGA2
     1  MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP
    61  THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG
   121  SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQGI IKQDPKLPVD KILPPPSPWP
   181  KSSIFDADEE KSKLLTRLLK SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS
   241  HVKVLQEMLS MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN
   301  DLLTQGVLLY KQVMEGRVTF GNRVTSSLGD IPVSRVFQNP AGCMKTCPLI DLEVDNGPAQ
   361  MGTVVPSLLH QDLAALGISD APVTGMVSGQ NCCEEKRNPS SSTLPGGGVQ NPSADRNLLD
   421  LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS PGWSWEAGPL APSPSSQNTP LAQVFVPLES
   481  VKPSSLPPLI VYDRNGFRIL LHFSQTGAPG HPEVQVLLLT MMSTAPQPVW DIMFQVAVPK
   541  SMRVKLQPAS SSKLPAFSPL MPPAVISQML LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE
   601  VKDFPDLAVL GAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 82 nTPM
  • retina: 74 nTPM
  • lymph node: 68 nTPM
  • pancreas: 52 nTPM
  • spleen: 43 nTPM
  • salivary gland: 36 nTPM

Single-cell type

  • rod photoreceptor cells: 405 nCPM
  • retinal pigment epithelial cells: 264 nCPM
  • cone photoreceptor cells: 228 nCPM
  • b-cells: 195 nCPM
  • retinal bipolar cells: 173 nCPM
  • retinal ganglion cells: 147 nCPM

Immune cell

  • naive B-cell: 22 nTPM
  • memory B-cell: 16 nTPM
  • plasmacytoid DC: 16 nTPM
  • eosinophil: 7.1 nTPM
  • myeloid DC: 4.9 nTPM
  • T-reg: 4.5 nTPM

Brain region

  • choroid plexus: 50 nTPM
  • cerebellum: 35 nTPM
  • hypothalamus: 34 nTPM
  • cerebral cortex: 26 nTPM
  • hippocampal formation: 25 nTPM
  • midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.15
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGA2 as an antibody target. Whether an autoantibody or antibody against GGA2 could matter depends on whether native GGA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GGA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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