Seroatlas · Human Serome Atlas

TSR1

Pre-rRNA-processing protein TSR1 homolog

Also known as: FLJ10534, TSR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2NL82
Gene: TSR1
Ensembl: ENSG00000167721
Chromosome: 17
Canonical length: 804 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

804 residues, UniProt reviewed canonical sequence.

>Q2NL82|TSR1
     1  MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR VDQRHRASQL
    61  RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM QLLQDRDTGT VHLNELGNTQ
   121  NFMLLCPRLK HRWFFTSARP GDLHVVLDMA KVADTILFLL DPLEGWDSTG DYCLSCLFAQ
   181  GLPTYTLAVQ GISGLPLKKQ IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK
   241  QQHLAFRDRR AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
   301  QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG RQESLQAEVI
   361  PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY QAEWILDGGS QSGGEGDEYE
   421  YDDMEHEDFM EEESQDESSE EEEEYETMTI GESVHDDLYD KKVDEEAEAK MLEKYKQERL
   481  EEMFPDEVDT PRDVAARIRF QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI
   541  FKEVEEKEVE GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
   601  DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL VATVYAPITF
   661  PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS GHPFKIFTKM AVVRYMFFNR
   721  EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD
   781  PYVPEPVPWL KSEISSTVPQ GGME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 51 nTPM
tongue: 29 nTPM
esophagus: 22 nTPM
urinary bladder: 21 nTPM
pancreas: 19 nTPM
skin: 19 nTPM

Single-cell type

late spermatids: 117 nCPM
early spermatids: 81 nCPM
differentiating spermatogonia: 68 nCPM
erythrocyte progenitors: 67 nCPM
esophageal basal cells: 58 nCPM
suprabasal keratinocytes: 57 nCPM

Immune cell

non-classical monocyte: 12 nTPM
myeloid DC: 12 nTPM
MAIT T-cell: 11 nTPM
intermediate monocyte: 11 nTPM
T-reg: 9.1 nTPM
naive CD8 T-cell: 9 nTPM

Brain region

spinal cord: 19 nTPM
thalamus: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM
midbrain: 17 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -1.36
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSR1 as an antibody target. Whether an autoantibody or antibody against TSR1 could matter depends on whether native TSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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