Seroatlas · Human Serome Atlas

NOB1

RNA-binding protein NOB1

Also known as: ART-4, MST158, NOB1_HUMAN, NOB1P, PSMD8BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULX3
Gene: NOB1
Ensembl: ENSG00000141101
Chromosome: 16
Canonical length: 412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites,Cytosol

OverviewNCBI Gene

In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q9ULX3|NOB1
     1  MAPVEHVVAD AGAFLRHAAL QDIGKNIYTI REVVTEIRDK ATRRRLAVLP YELRFKEPLP
    61  EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV SHLKQEPQKV KVSSSIQHPE
   121  TPLHISGFHL PYKPKPPQET EKGHSACEPE NLEFSSFMFW RNPLPNIDHE LQELLIDRGE
   181  DVPSEEEEEE ENGFEDRKDD SDDDGGGWIT PSNIKQIQQE LEQCDVPEDV RVGCLTTDFA
   241  MQNVLLQMGL HVLAVNGMLI REARSYILRC HGCFKTTSDM SRVFCSHCGN KTLKKVSVTV
   301  SDDGTLHMHF SRNPKVLNPR GLRYSLPTPK GGKYAINPHL TEDQRFPQLR LSQKARQKTN
   361  VFAPDYIAGV SPFVENDISS RSATLQVRDS TLGAGRRRLN PNASRKKFVK KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

pancreas: 86 nTPM
ovary: 55 nTPM
adrenal gland: 50 nTPM
skin: 41 nTPM
fallopian tube: 41 nTPM
esophagus: 41 nTPM

Single-cell type

oocytes: 281 nCPM
esophageal basal cells: 160 nCPM
decidual stromal cells: 134 nCPM
migrating cytotrophoblasts: 98 nCPM
pancreatic acinar cells: 96 nCPM
extravillous trophoblasts: 94 nCPM

Immune cell

T-reg: 68 nTPM
NK-cell: 66 nTPM
MAIT T-cell: 58 nTPM
naive B-cell: 54 nTPM
naive CD4 T-cell: 54 nTPM
myeloid DC: 51 nTPM

Brain region

basal ganglia: 28 nTPM
choroid plexus: 28 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 22 nTPM
pons: 21 nTPM
cerebellum: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NOB1.

Disease | ImmuneIEDB

Conditions an epitope on NOB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.61
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PIN domain
Putative WW-binding domain and destruction box
Putative WW-binding domain and destruction box
Nin one binding (NOB1), Zn-ribbon-like domain
Ribonuclease Nob1, eukaryote
Ribonuclease, PIN domain
NOB1 zinc finger-like superfamily
RNA-binding protein NOB1
Nin one binding (NOB1) Zn-ribbon like
PIN domain of ribonuclease

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOB1 as an antibody target. Whether an autoantibody or antibody against NOB1 could matter depends on whether native NOB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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