Seroatlas · Human Serome Atlas

RRP12

RRP12-like protein

Also known as: KIAA0690, RRP12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JTH9
Gene: RRP12
Ensembl: ENSG00000052749
Chromosome: 10
Canonical length: 1297 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in cytosol; nucleolus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1297 residues, UniProt reviewed canonical sequence.

>Q5JTH9|RRP12
     1  MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD LTVDAVKLHN
    61  ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA
   121  HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS
   181  PVLIKKFSDT SKAFMDIMSA QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG
   241  LLSFTVHPKP KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
   301  ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH SLFHARPGLS
   361  TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN LVRLQWDLGL GHLPRFFGTA
   421  VTCLLSPHSQ VLTAATQSLK EILKECVAPH MADIGSVTSS ASGPAQSVAK MFRAVEEGLT
   481  YKFHAAWSSV LQLLCVFFEA CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT
   541  SMGPEVVLQA VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
   601  MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA ISERPDLRVT
   661  VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP VAAGDTPAPR RAVLETIRTY
   721  LTITDTQLVN SLLEKASEKV LDPASSDFTR LSVLDLVVAL APCADEAAIS KLYSTIRPYL
   781  ESKAHGVQKK AYRVLEEVCA SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL
   841  LHIVRKLSAE HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
   901  CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL LASRTRDVVK
   961  SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF RMKLRNLFTK FIRKFGFELV
  1021  KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ AAVEEEEEEE EEEEPAQGKG DSIEEILADS
  1081  EDEEDNEEEE RSRGKEQRKL ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR
  1141  KKDHGFKVSA DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
  1201  AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP YAYIPLNRSK
  1261  LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 86 nTPM
skeletal muscle: 36 nTPM
pancreas: 15 nTPM
heart muscle: 11 nTPM
testis: 10 nTPM
skin: 9.7 nTPM

Single-cell type

monocyte progenitors: 319 nCPM
neutrophil progenitors: 288 nCPM
neutrophils: 285 nCPM
kupffer cells: 222 nCPM
monocytes: 176 nCPM
megakaryocyte progenitors: 143 nCPM

Immune cell

neutrophil: 27 nTPM
non-classical monocyte: 17 nTPM
intermediate monocyte: 14 nTPM
classical monocyte: 11 nTPM
eosinophil: 6.9 nTPM
myeloid DC: 6.2 nTPM

Brain region

cerebral cortex: 35 nTPM
midbrain: 29 nTPM
pons: 29 nTPM
white matter: 28 nTPM
thalamus: 28 nTPM
basal ganglia: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRP12.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 263 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Basal ganglia calcification, idiopathic, 11, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -1.31
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
RRP12, HEAT domain
Ribosomal RNA-processing protein RRP12
RRP12, N-terminal HEAT domain
Ribosomal RNA-processing protein 12, HEAT repeats
RRP12-like, N-terminal HEAT repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRP12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP12 as an antibody target. Whether an autoantibody or antibody against RRP12 could matter depends on whether native RRP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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