Seroatlas · Human Serome Atlas

PPP4R2

Serine/threonine-protein phosphatase 4 regulatory subunit 2

Also known as: PP4R2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY27
Gene
PPP4R2
Ensembl
ENSG00000163605
Chromosome
3
Canonical length
417 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q9NY27|PPP4R2
     1  MDVERLQEAL KDFEKRGKKE VCPVLDQFLC HVAKTGETMI QWSQFKGYFI FKLEKVMDDF
    61  RTSAPEPRGP PNPNVEYIPF DEMKERILKI VTGFNGIPFT IQRLCELLTD PRRNYTGTDK
   121  FLRGVEKNVM VVSCVYPSSE KNNSNSLNRM NGVMFPGNSP SYTERSNING PGTPRPLNRP
   181  KVSLSAPMTT NGLPESTDSK EANLQQNEEK NHSDSSTSES EVSSVSPLKN KHPDEDAVEA
   241  EGHEVKRLRF DKEGEVRETA SQTTSSEISS VMVGETEASS SSQDKDKDSR CTRQHCTEED
   301  EEEDEEEEEE SFMTSREMIP ERKNQEKESD DALTVNEETS EENNQMEESD VSQAEKDLLH
   361  SEGSENEGPV SSSSSDCRET EELVGSNSSK TGEILSESSM ENDDEATEVT DEPMEQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP4R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 96 nTPM
  • liver: 50 nTPM
  • thymus: 34 nTPM
  • placenta: 27 nTPM
  • cervix: 26 nTPM
  • fallopian tube: 26 nTPM

Single-cell type

  • neutrophils: 1,114 nCPM
  • neutrophil progenitors: 381 nCPM
  • fallopian secretory cells: 249 nCPM
  • sertoli cells: 198 nCPM
  • syncytiotrophoblasts: 197 nCPM
  • endometrial glandular cells: 186 nCPM

Immune cell

  • neutrophil: 21 nTPM
  • plasmacytoid DC: 18 nTPM
  • T-reg: 18 nTPM
  • eosinophil: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • memory CD8 T-cell: 13 nTPM

Brain region

  • white matter: 95 nTPM
  • cerebellum: 66 nTPM
  • basal ganglia: 65 nTPM
  • choroid plexus: 63 nTPM
  • medulla oblongata: 63 nTPM
  • cerebral cortex: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
0
DepMap mean gene effect
-0.64
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein phosphatase 4 core regulatory subunit R2
  • PPP4R2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP4R2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP4R2 as an antibody target. Whether an autoantibody or antibody against PPP4R2 could matter depends on whether native PPP4R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP4R2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP4R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP4R2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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