Seroatlas · Human Serome Atlas

SF3B5

Splicing factor 3B subunit 5

Also known as: MGC3133, SF3b10, SF3B5_HUMAN, Ysf3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWJ5
Gene: SF3B5
Ensembl: ENSG00000169976
Chromosome: 6
Canonical length: 86 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

86 residues, UniProt reviewed canonical sequence.

>Q9BWJ5|SF3B5
     1  MTDRYTIHSQ LEHLQSKYIG TGHADTTKWE WLVNQHRDSY CSYMGHFDLL NYFAIAENES
    61  KARVRFNLME KMLQPCGPPA DKPEEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SF3B5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 238 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 238 nTPM
choroid plexus: 214 nTPM
liver: 185 nTPM
adrenal gland: 176 nTPM
kidney: 168 nTPM
skeletal muscle: 154 nTPM

Single-cell type

esophageal suprabasal cells: 671 nCPM
esophageal basal cells: 564 nCPM
esophageal apical cells: 433 nCPM
gastric progenitor cells: 391 nCPM
hofbauer cells: 383 nCPM
decidual stromal cells: 383 nCPM

Immune cell

classical monocyte: 379 nTPM
plasmacytoid DC: 365 nTPM
total PBMC: 364 nTPM
myeloid DC: 327 nTPM
intermediate monocyte: 278 nTPM
non-classical monocyte: 258 nTPM

Brain region

cerebellum: 89 nTPM
white matter: 86 nTPM
choroid plexus: 83 nTPM
medulla oblongata: 83 nTPM
pons: 82 nTPM
thalamus: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.58
gnomAD missense Z: 1.19
DepMap mean gene effect: -2.76
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Splicing factor 3B subunit 5/RDS3 complex subunit 10
Splicing factor 3B, subunit 5
Splicing factor 3B subunit 10 (SF3b10)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SF3B5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SF3B5 as an antibody target. Whether an autoantibody or antibody against SF3B5 could matter depends on whether native SF3B5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SF3B5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SF3B5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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