Seroatlas · Human Serome Atlas

SNW1

SNW domain-containing protein 1

Also known as: Bx42, FUN20, NCoA-62, Prp45, PRPF45, SKIIP, SKIP, SKIP1, SNW1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13573
Gene: SNW1
Ensembl: ENSG00000100603
Chromosome: 14
Canonical length: 536 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>Q13573|SNW1
     1  MALTSFLPAP TQLSQDQLEA EEKARSQRSR QTSLVSSRRE PPPYGYRKGW IPRLLEDFGD
    61  GGAFPEIHVA QYPLDMGRKK KMSNALAIQV DSEGKIKYDA IARQGQSKDK VIYSKYTDLV
   121  PKEVMNADDP DLQRPDEEAI KEITEKTRVA LEKSVSQKVA AAMPVRAADK LAPAQYIRYT
   181  PSQQGVAFNS GAKQRVIRMV EMQKDPMEPP RFKINKKIPR GPPSPPAPVM HSPSRKMTVK
   241  EQQEWKIPPC ISNWKNAKGY TIPLDKRLAA DGRGLQTVHI NENFAKLAEA LYIADRKARE
   301  AVEMRAQVER KMAQKEKEKH EEKLREMAQK ARERRAGIKT HVEKEDGEAR ERDEIRHDRR
   361  KERQHDRNLS RAAPDKRSKL QRNENRDISE VIALGVPNPR TSNEVQYDQR LFNQSKGMDS
   421  GFAGGEDEIY NVYDQAWRGG KDMAQSIYRP SKNLDKDMYG DDLEARIKTN RFVPDKEFSG
   481  SDRRQRGREG PVQFEEDPFG LDKFLEEAKQ HGGSKRPSDS SRPKEHEHEG KKRRKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNW1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 86 nTPM
skeletal muscle: 63 nTPM
skin: 49 nTPM
testis: 47 nTPM
thymus: 46 nTPM
adipose tissue: 46 nTPM

Single-cell type

late primary spermatocytes: 305 nCPM
early primary spermatocytes: 235 nCPM
oocytes: 230 nCPM
erythrocyte progenitors: 189 nCPM
megakaryocytes: 161 nCPM
platelets: 153 nCPM

Immune cell

eosinophil: 96 nTPM
NK-cell: 95 nTPM
T-reg: 95 nTPM
basophil: 95 nTPM
non-classical monocyte: 93 nTPM
intermediate monocyte: 77 nTPM

Brain region

white matter: 34 nTPM
cerebellum: 30 nTPM
pons: 28 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 27 nTPM
choroid plexus: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNW1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

SNW1-associated neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.85
DepMap mean gene effect: -1.52
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SKI-interacting protein SKIP, SNW domain
SKI-interacting protein, SKIP
SKIP/SNW domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNW1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNW1 as an antibody target. Whether an autoantibody or antibody against SNW1 could matter depends on whether native SNW1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNW1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNW1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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