Seroatlas · Human Serome Atlas

GPATCH11

G patch domain-containing protein 11

Also known as: GPT11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N954
Gene
GPATCH11
Canonical length
285 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GPATCH11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q8N954|GPATCH11
     1  MRSARSTALN RGEQRAVRYY SHMKLNMAEE EDYMSDSFIN VQEDIRPGLP MLRQIREARR
    61  KEEKQQEANL KNRQKSLKEE EQERRDIGLK NALGCENKGF ALLQKMGYKS GQALGKSGGG
   121  IVEPIPLNIK TGKSGIGHEA SLKRKAEEKL ESYRKKIHMK NQAEEKAAEQ FRMRLKNKQD
   181  EMKLEGDLRR SQRACQQLDV QKNIQVPREA WYWLRLEEET EEDEEEKEQD EDEYKSEDLS
   241  VLEKLQILTS YLREEHLYCI WCGTAYEDKE DLSSNCPGPT SADHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 22 nTPM
  • retina: 20 nTPM
  • lymph node: 12 nTPM
  • cerebral cortex: 11 nTPM
  • tonsil: 11 nTPM
  • testis: 11 nTPM

Single-cell type

  • late primary spermatocytes: 106 nCPM
  • early primary spermatocytes: 64 nCPM
  • rod photoreceptor cells: 62 nCPM
  • pdcs: 62 nCPM
  • erythrocyte progenitors: 58 nCPM
  • oocytes: 55 nCPM

Immune cell

  • plasmacytoid DC: 12 nTPM
  • memory B-cell: 8.4 nTPM
  • naive B-cell: 6.7 nTPM
  • NK-cell: 6.7 nTPM
  • basophil: 5.8 nTPM
  • MAIT T-cell: 4.4 nTPM

Brain region

  • white matter: 18 nTPM
  • hypothalamus: 15 nTPM
  • cerebellum: 15 nTPM
  • spinal cord: 15 nTPM
  • medulla oblongata: 15 nTPM
  • basal ganglia: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPATCH11.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Early onset and severe retinal dystrophy with neurological impairment and facial dysmorphia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH11 as an antibody target. Whether an autoantibody or antibody against GPATCH11 could matter depends on whether native GPATCH11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPATCH11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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