Seroatlas · Human Serome Atlas

SLC4A1AP

Kanadaptin

Also known as: HLC3, kanadaptin, NADAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWU0
Gene: SLC4A1AP
Ensembl: ENSG00000163798
Chromosome: 2
Canonical length: 742 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable mRNA binding activity. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

742 residues, UniProt reviewed canonical sequence.

>Q9BWU0|SLC4A1AP
     1  MADILSQSET LASQDLSGDF KKPALPVSPA ARSKAPASSS SNPEEVQKEG PTALQDSNSG
    61  EPDIPPPQPD CGDFRSLQEE QSRPPTAVSS PGGPARAPPY QEPPWGGPAT APYSLETLKG
   121  GTILGTRSLK GTSYCLFGRL SGCDVCLEHP SVSRYHAVLQ HRASGPDGEC DSNGPGFYLY
   181  DLGSTHGTFL NKTRIPPRTY CRVHVGHVVR FGGSTRLFIL QGPEEDREAE SELTVTQLKE
   241  LRKQQQILLE KKMLGEDSDE EEEMDTSERK INAGSQDDEM GCTWGMGEDA VEDDAEENPI
   301  VLEFQQEREA FYIKDPKKAL QGFFDREGEE LEYEFDEQGH STWLCRVRLP VDDSTGKQLV
   361  AEAIHSGKKK EAMIQCSLEA CRILDTLGLL RQEAVSRKRK AKNWEDEDFY DSDDDTFLDR
   421  TGLIEKKRLN RMKKAGKIDE KPETFESLVA KLNDAERELS EISERLKASS QVLSESPSQD
   481  SLDAFMSEMK SGSTLDGVSR KKLHLRTFEL RKEQQRLKGL IKIVKPAEIP ELKKTETQTT
   541  GAENKAKKLT LPLFGAMKGG SKFKLKTGTV GKLPPKRPEL PPTLMRMKDE PEVEEEEEEE
   601  EEEEKEKEEH EKKKLEDGSL SRPQPEIEPE AAVQEMRPPT DLTHFKETQT HENMSQLSEE
   661  EQNKDYQDCS KTTSLCAGPS ASKNEYEKSR GELKKKKTPG PGKLPPTLSS KYPEDDPDYC
   721  VWVPPEGQSG DGRTHLNDKY GY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A1AP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 29 nTPM
testis: 28 nTPM
cerebellum: 25 nTPM
cerebral cortex: 24 nTPM
tongue: 21 nTPM
parathyroid gland: 19 nTPM

Single-cell type

early primary spermatocytes: 148 nCPM
late primary spermatocytes: 102 nCPM
esophageal apical cells: 83 nCPM
differentiating spermatogonia: 74 nCPM
cardiomyocytes: 68 nCPM
breast lactating cells: 58 nCPM

Immune cell

basophil: 98 nTPM
eosinophil: 47 nTPM
NK-cell: 42 nTPM
naive B-cell: 36 nTPM
non-classical monocyte: 35 nTPM
T-reg: 34 nTPM

Brain region

cerebral cortex: 16 nTPM
white matter: 16 nTPM
cerebellum: 16 nTPM
basal ganglia: 14 nTPM
hypothalamus: 14 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC4A1AP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A1AP as an antibody target. Whether an autoantibody or antibody against SLC4A1AP could matter depends on whether native SLC4A1AP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A1AP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC4A1AP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...