Seroatlas · Human Serome Atlas

SUGP1

SURP and G-patch domain-containing protein 1

Also known as: DKFZp434E2216, F23858, RBP, SF4, SUGP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWZ8
Gene
SUGP1
Ensembl
ENSG00000105705
Chromosome
19
Canonical length
645 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q8IWZ8|SUGP1
     1  MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM EQKAKQNQVA
    61  SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ TSTDAPTSAP SAPPSTPTPS
   121  AGKRSLLISR RTGLGLASLP GPVKSYSHAK QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV
   181  SPPEGAETRK VIEKLARFVA EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE
   241  IRKEAQKSQA ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE
   301  PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA TTCPASSTPA
   361  PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE LVQRDVDASP SPLSVQDLKG
   421  LGYEKGKPVG LVGVTELSDA QKKQLKEQQE MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ
   481  HGYDSDEEVD SELGTWEHQL RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET
   541  FKALKEGREP DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD
   601  GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 13 nTPM
  • testis: 12 nTPM
  • heart muscle: 8.7 nTPM
  • blood vessel: 6.6 nTPM
  • esophagus: 6.6 nTPM
  • cerebral cortex: 6.5 nTPM

Single-cell type

  • late spermatids: 175 nCPM
  • late primary spermatocytes: 70 nCPM
  • oocytes: 69 nCPM
  • tuft cells: 58 nCPM
  • early spermatids: 44 nCPM
  • gonadotrophs: 43 nCPM

Immune cell

  • non-classical monocyte: 14 nTPM
  • NK-cell: 11 nTPM
  • intermediate monocyte: 11 nTPM
  • neutrophil: 10 nTPM
  • total PBMC: 9.5 nTPM
  • memory CD8 T-cell: 9.4 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • white matter: 11 nTPM
  • midbrain: 11 nTPM
  • hypothalamus: 9.7 nTPM
  • pons: 9.5 nTPM
  • medulla oblongata: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
1.21
DepMap mean gene effect
-0.63
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUGP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUGP1 as an antibody target. Whether an autoantibody or antibody against SUGP1 could matter depends on whether native SUGP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUGP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUGP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUGP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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