Seroatlas · Human Serome Atlas

SNAP29

Synaptosomal-associated protein 29

Also known as: CEDNIK, SNAP-29, SNP29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95721
Gene
SNAP29
Ensembl
ENSG00000099940
Chromosome
22
Canonical length
258 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol

OverviewNCBI Gene

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O95721|SNAP29
     1  MSAYPKSYNP FDDDGEDEGA RPAPWRDARD LPDGPDAPAD RQQYLRQEVL RRAEATAAST
    61  SRSLALMYES EKVGVASSEE LARQRGVLER TEKMVDKMDQ DLKISQKHIN SIKSVFGGLV
   121  NYFKSKPVET PPEQNGTLTS QPNNRLKEAI STSKEQEAKY QASHPNLRKL DDTDPVPRGA
   181  GSAMSTDAYP KNPHLRAYHQ KIDSNLDELS MGLGRLKDIA LGMQTEIEEQ DDILDRLTTK
   241  VDKLDVNIKS TERKVRQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAP29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • testis: 54 nTPM
  • liver: 33 nTPM
  • skeletal muscle: 29 nTPM
  • tongue: 26 nTPM
  • choroid plexus: 23 nTPM
  • thymus: 23 nTPM

Single-cell type

  • late primary spermatocytes: 489 nCPM
  • early spermatids: 488 nCPM
  • esophageal apical cells: 321 nCPM
  • extravillous trophoblasts: 213 nCPM
  • platelets: 212 nCPM
  • late spermatids: 193 nCPM

Immune cell

  • non-classical monocyte: 78 nTPM
  • intermediate monocyte: 62 nTPM
  • NK-cell: 60 nTPM
  • eosinophil: 53 nTPM
  • basophil: 49 nTPM
  • neutrophil: 49 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • medulla oblongata: 23 nTPM
  • cerebellum: 23 nTPM
  • white matter: 22 nTPM
  • hippocampal formation: 21 nTPM
  • pons: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNAP29.

Disease | AllUniProt

Conditions SNAP29 is implicated in, by any mechanism.

  • Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK) MIM:609528

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 356 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.01
gnomAD missense Z
-0.87
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAP29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAP29 as an antibody target. Whether an autoantibody or antibody against SNAP29 could matter depends on whether native SNAP29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAP29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNAP29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNAP29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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