Seroatlas · Human Serome Atlas

LURAP1

Leucine rich adaptor protein 1

Also known as: C1orf190, FLJ25163, LRAP35a, LURA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LR2
Gene: LURAP1
Ensembl: ENSG00000171357
Chromosome: 1
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of cytokine production. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q96LR2|LURAP1
     1  MEGTVESQTP DLRDVEGKVG RKTPEGLLRG LRGECELGTS GALLLPGASS TGHDLGDKIM
    61  ALKMELAYLR AIDVKILQQL VTLNEGIEAV RWLLEERGTL TSHCSSLTSS QYSLTGGSPG
   121  RSRRGSWDSL PDTSTTDRLD SVSIGSFLDT VAPSELDEQG PPGAPRSEMD WAKVIAGGER
   181  ARTEVDVAAT RLGSLRAVWK PPGERLQGGP PESPEDESAK LGFEAHWFWE QCQDDVTFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LURAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 12 nTPM
thyroid gland: 9.9 nTPM
testis: 9.5 nTPM
parathyroid gland: 8.9 nTPM
blood vessel: 8.5 nTPM
choroid plexus: 7.4 nTPM

Single-cell type

late spermatids: 510 nCPM
endometrial luminal cells: 169 nCPM
late primary spermatocytes: 135 nCPM
early spermatids: 132 nCPM
renal connecting tubule cells: 60 nCPM
endometrial glandular cells: 41 nCPM

Immune cell

neutrophil: 0.7 nTPM
MAIT T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM

Brain region

white matter: 44 nTPM
medulla oblongata: 37 nTPM
pons: 32 nTPM
basal ganglia: 30 nTPM
thalamus: 30 nTPM
cerebellum: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.01
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LURAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LURAP1 as an antibody target. Whether an autoantibody or antibody against LURAP1 could matter depends on whether native LURAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LURAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LURAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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