Seroatlas · Human Serome Atlas

VAMP2

Vesicle-associated membrane protein 2

Also known as: SYB2, VAMP-2, VAMP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P63027
Gene
VAMP2
Ensembl
ENSG00000220205
Chromosome
17
Canonical length
116 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>P63027|VAMP2
     1  MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL
    61  SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
464 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 464 nTPM
  • retina: 418 nTPM
  • cerebellum: 368 nTPM
  • amygdala: 322 nTPM
  • hippocampal formation: 309 nTPM
  • basal ganglia: 292 nTPM

Single-cell type

  • other brain neurons: 333 nCPM
  • brain inhibitory neurons: 253 nCPM
  • brain excitatory neurons: 239 nCPM
  • oligodendrocytes: 150 nCPM
  • oligodendrocyte progenitor cells: 96 nCPM
  • bergmann glia: 90 nCPM

Immune cell

  • neutrophil: 114 nTPM
  • naive CD4 T-cell: 93 nTPM
  • memory CD8 T-cell: 86 nTPM
  • naive CD8 T-cell: 86 nTPM
  • memory B-cell: 80 nTPM
  • memory CD4 T-cell: 80 nTPM

Brain region

  • cerebral cortex: 699 nTPM
  • basal ganglia: 591 nTPM
  • hypothalamus: 576 nTPM
  • midbrain: 552 nTPM
  • white matter: 549 nTPM
  • pons: 547 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VAMP2.

Disease | AllUniProt

Conditions VAMP2 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements (NEDHAHM) MIM:618760

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements
  • Severe neurodevelopmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.89
gnomAD missense Z
1.41
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAMP2 as an antibody target. Whether an autoantibody or antibody against VAMP2 could matter depends on whether native VAMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAMP2 is annotated at the cell surface, where native VAMP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VAMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VAMP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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