Seroatlas · Human Serome Atlas

SCFD1

Sec1 family domain-containing protein 1

Also known as: C14orf163, KIAA0917, RA410, SCFD1_HUMAN, SLY1, STXBP1L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVM8
Gene
SCFD1
Ensembl
ENSG00000092108
Chromosome
14
Canonical length
642 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q8WVM8|SCFD1
     1  MAAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR FGQDIISPLL
    61  SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID RMCQDLRNQL YESYYLNFIS
   121  AISRSKLEDI ANAALAASAV TQVAKVFDQY LNFITLEDDM FVLCNQNKEL VSYRAINRPD
   181  ITDTEMETVM DTIVDSLFCF FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL
   241  FTGDTLGAGQ FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV
   301  ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA QEDEVKRLKS
   361  IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID LHTNVATAVL EHIKARKLDV
   421  YFEYEEKIMS KTTLDKSLLD IISDPDAGTP EDKMRLFLIY YISTQQAPSE ADLEQYKKAL
   481  TDAGCNLNPL QYIKQWKAFT KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL
   541  KQQNLPVTRI LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN
   601  YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCFD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 49 nTPM
  • pancreas: 44 nTPM
  • thyroid gland: 42 nTPM
  • parathyroid gland: 39 nTPM
  • epididymis: 39 nTPM
  • liver: 33 nTPM

Single-cell type

  • somatotrophs: 404 nCPM
  • lactotrophs: 375 nCPM
  • gonadotrophs: 374 nCPM
  • corticotrophs: 362 nCPM
  • neutrophil progenitors: 349 nCPM
  • plasma cells: 345 nCPM

Immune cell

  • non-classical monocyte: 28 nTPM
  • basophil: 27 nTPM
  • T-reg: 24 nTPM
  • myeloid DC: 24 nTPM
  • intermediate monocyte: 23 nTPM
  • NK-cell: 23 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • hypothalamus: 8.9 nTPM
  • basal ganglia: 8.5 nTPM
  • cerebellum: 8.3 nTPM
  • cerebral cortex: 8.3 nTPM
  • midbrain: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
2.05
DepMap mean gene effect
-1.39
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCFD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCFD1 as an antibody target. Whether an autoantibody or antibody against SCFD1 could matter depends on whether native SCFD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCFD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCFD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCFD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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