Seroatlas · Human Serome Atlas

EIPR1

EARP and GARP complex-interacting protein 1

Also known as: EIPR-1, EIPR1_HUMAN, TSSC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53HC9
Gene
EIPR1
Ensembl
ENSG00000032389
Chromosome
2
Canonical length
387 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Intermediate filaments

OverviewNCBI Gene

This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q53HC9|EIPR1
     1  MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL
    61  LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR MPKELESGSH ESPDDSSSTA
   121  QTLELLCHLD NTAHGNMACV VWEPMGDGKK IISLADNHIL LWDLQESSSQ AVLASSASLE
   181  GKGQLKFTSG RWSPHHNCTQ VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK
   241  QYYLASCGDD CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS
   301  NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV YAVDWSSADP
   361  WLFASLSYDG RLVINRVPRA LKYHILL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 33 nTPM
  • cerebral cortex: 31 nTPM
  • pituitary gland: 29 nTPM
  • amygdala: 28 nTPM
  • hypothalamus: 27 nTPM
  • hippocampal formation: 25 nTPM

Single-cell type

  • retinal horizontal cells: 138 nCPM
  • lactotrophs: 109 nCPM
  • corticotrophs: 107 nCPM
  • oocytes: 106 nCPM
  • renal collecting duct intercalated cells: 106 nCPM
  • thyrotrophs: 98 nCPM

Immune cell

  • plasmacytoid DC: 30 nTPM
  • myeloid DC: 27 nTPM
  • NK-cell: 22 nTPM
  • basophil: 22 nTPM
  • T-reg: 22 nTPM
  • naive B-cell: 21 nTPM

Brain region

  • hypothalamus: 28 nTPM
  • cerebral cortex: 27 nTPM
  • basal ganglia: 26 nTPM
  • hippocampal formation: 25 nTPM
  • cerebellum: 24 nTPM
  • pons: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIPR1.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 69 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, HYPOPLASIA OF THE CORPUS CALLOSUM, AND RECURRENT INFECTIONS

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.06
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIPR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIPR1 as an antibody target. Whether an autoantibody or antibody against EIPR1 could matter depends on whether native EIPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIPR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIPR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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