Seroatlas · Human Serome Atlas

EXOC1

Exocyst complex component 1

Also known as: BM-102, EXOC1_HUMAN, FLJ10893, SEC3, SEC3L1, Sec3p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NV70
Gene
EXOC1
Ensembl
ENSG00000090989
Chromosome
4
Canonical length
894 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Plasma membrane,Microtubules,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

894 residues, UniProt reviewed canonical sequence.

>Q9NV70|EXOC1
     1  MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK
    61  GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ
   121  RYLRKKIDFV NVSSQLLEES VPSGENQSVT GGDEEVVDEY QELNAREEQD IEIMMEGCEY
   181  AISNAEAFAE KLSRELQVLD GANIQSIMAS EKQVNILMKL LDEALKEVDQ IELKLSSYEE
   241  MLQSVKEQMD QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLASSRG
   301  IEACTNAADA LLQCMNVALR PGHDLLLAVK QQQQRFSDLR ELFARRLASH LNNVFVQQGH
   361  DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY GKYEGLTKNY MDYLSRLYER
   421  EIKDFFEVAK IKMTGTTKES KKFATLPRKE SAVKQETESL HGSSGKLTGS TSSLNKLSVQ
   481  SSGNRRSQSS SLLDMGNMSA SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ
   541  QHQSMPGTMA EAEDLDGGTL SRQHNCGTPL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL
   601  GDKIDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC ISNQIRQMEE
   661  VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK AYTKLIRGVF VNVEKVANES
   721  QKTPRDVVMM ENFHHIFATL SRLKISCLEA EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH
   781  FFEGVEARVA QGIREEEVSY QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE
   841  NLLQVVWHSM QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 28 nTPM
  • skin: 27 nTPM
  • spinal cord: 22 nTPM
  • cerebral cortex: 22 nTPM
  • spleen: 20 nTPM
  • placenta: 20 nTPM

Single-cell type

  • esophageal apical cells: 202 nCPM
  • adrenal cortex cells: 159 nCPM
  • thyrotrophs: 156 nCPM
  • oligodendrocytes: 148 nCPM
  • lactotrophs: 145 nCPM
  • esophageal suprabasal cells: 135 nCPM

Immune cell

  • non-classical monocyte: 24 nTPM
  • basophil: 21 nTPM
  • neutrophil: 20 nTPM
  • intermediate monocyte: 19 nTPM
  • classical monocyte: 15 nTPM
  • myeloid DC: 14 nTPM

Brain region

  • white matter: 38 nTPM
  • medulla oblongata: 33 nTPM
  • thalamus: 31 nTPM
  • spinal cord: 30 nTPM
  • cerebellum: 30 nTPM
  • pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0
gnomAD missense Z
2.11
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC1 as an antibody target. Whether an autoantibody or antibody against EXOC1 could matter depends on whether native EXOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC1 is annotated at the cell surface, where native EXOC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EXOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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