Seroatlas · Human Serome Atlas

VAMP4

Vesicle-associated membrane protein 4

Also known as: VAMP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75379
Gene: VAMP4
Ensembl: ENSG00000117533
Chromosome: 1
Canonical length: 141 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>O75379|VAMP4
     1  MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV
    61  DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKIKAIM
   121  ALVAAILLLV IIILIVMKYR T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
blood vessel: 17 nTPM
pituitary gland: 14 nTPM
cerebral cortex: 13 nTPM
parathyroid gland: 12 nTPM
adrenal gland: 11 nTPM

Single-cell type

esophageal apical cells: 92 nCPM
late spermatids: 60 nCPM
late primary spermatocytes: 59 nCPM
lactotrophs: 56 nCPM
megakaryocytes: 50 nCPM
platelets: 45 nCPM

Immune cell

MAIT T-cell: 12 nTPM
eosinophil: 12 nTPM
memory CD4 T-cell: 11 nTPM
T-reg: 11 nTPM
basophil: 11 nTPM
memory CD8 T-cell: 9.9 nTPM

Brain region

thalamus: 26 nTPM
cerebellum: 24 nTPM
midbrain: 24 nTPM
hypothalamus: 24 nTPM
pons: 24 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.14
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to type II interferon
endocytic recycling
Golgi ribbon formation
Golgi to plasma membrane protein transport
neurotransmitter receptor transport, endosome to postsynaptic membrane
regulation of synaptic vesicle endocytosis
SNARE complex assembly
synaptic vesicle to endosome fusion
vesicle-mediated transport in synapse
regulation of Golgi to plasma membrane protein transport

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAMP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAMP4 as an antibody target. Whether an autoantibody or antibody against VAMP4 could matter depends on whether native VAMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAMP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VAMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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