Seroatlas · Human Serome Atlas

STX8

Syntaxin-8

Also known as: CARB, STX8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNK0
Gene: STX8
Ensembl: ENSG00000170310
Chromosome: 17
Canonical length: 236 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q9UNK0|STX8
     1  MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD
    61  LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA
   121  PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
   181  EIIDDLANLV ENTDEKLRNE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 73 nTPM
testis: 67 nTPM
epididymis: 61 nTPM
tongue: 58 nTPM
blood vessel: 56 nTPM
skeletal muscle: 55 nTPM

Single-cell type

late spermatids: 1,547 nCPM
oocytes: 1,174 nCPM
early spermatids: 274 nCPM
neutrophil progenitors: 267 nCPM
late primary spermatocytes: 246 nCPM
distal convoluted tubule cells: 239 nCPM

Immune cell

T-reg: 199 nTPM
total PBMC: 198 nTPM
NK-cell: 168 nTPM
eosinophil: 160 nTPM
classical monocyte: 143 nTPM
myeloid DC: 143 nTPM

Brain region

cerebral cortex: 27 nTPM
white matter: 27 nTPM
medulla oblongata: 24 nTPM
choroid plexus: 24 nTPM
spinal cord: 23 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.54
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Target SNARE coiled-coil homology domain
Syntaxin
SNARE domain
Syntaxin-8, SNARE domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX8 as an antibody target. Whether an autoantibody or antibody against STX8 could matter depends on whether native STX8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX8 is annotated at the cell surface, where native STX8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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