Seroatlas · Human Serome Atlas

FAM9C

Protein FAM9C

Also known as: FAM9C_HUMAN, TEX39C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZT9
Gene: FAM9C
Ensembl: ENSG00000187268
Chromosome: X
Canonical length: 166 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q8IZT9|FAM9C
     1  MAAKDQLEVQ VMAAQEMELA GKDPVSHEHE ERKPVTETKE GDVTDEHGER GSFAETDEHT
    61  GVDTKELEDI AADIKEHLAA KRKRIEKIAK ACSEIKNRIK NVLRTTQLKR QKRDYRISLK
   121  LPNVLEEFIT DEQKDEEGDG EKEEQIKIFQ EQQKRWQQDG KGTERD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM9C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

spleen: 36 nTPM
testis: 4 nTPM
ovary: 1.2 nTPM
heart muscle: 0.9 nTPM
placenta: 0.6 nTPM
prostate: 0.4 nTPM

Single-cell type

early primary spermatocytes: 126 nCPM
differentiating spermatogonia: 12 nCPM
oocytes: 9.2 nCPM
vascular endothelial cells: 6.6 nCPM
undifferentiated spermatogonia: 3.7 nCPM
lymphatic endothelial cells: 3 nCPM

Immune cell

eosinophil: 0.7 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.4 nTPM
amygdala: 1.1 nTPM
basal ganglia: 0.9 nTPM
hippocampal formation: 0.8 nTPM
midbrain: 0.7 nTPM
cerebral cortex: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

synaptonemal complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of FAM9C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM9C as an antibody target. Whether an autoantibody or antibody against FAM9C could matter depends on whether native FAM9C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM9C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM9C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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