Seroatlas · Human Serome Atlas

STX5

Syntaxin-5

Also known as: SED5, STX5_HUMAN, STX5A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13190
Gene
STX5
Ensembl
ENSG00000162236
Chromosome
11
Canonical length
355 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q13190|STX5
     1  MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVTLVPP PPDTMSCRDR
    61  TQEFLSACKS LQTRQNGIQT NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK
   121  RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ
   181  SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESHAS
   241  KDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
   301  IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 49 nTPM
  • pancreas: 48 nTPM
  • liver: 48 nTPM
  • choroid plexus: 47 nTPM
  • prostate: 41 nTPM
  • epididymis: 40 nTPM

Single-cell type

  • esophageal apical cells: 324 nCPM
  • syncytiotrophoblasts: 319 nCPM
  • neutrophils: 266 nCPM
  • epididymal principal cells: 227 nCPM
  • late spermatids: 222 nCPM
  • epididymal basal cells: 198 nCPM

Immune cell

  • eosinophil: 36 nTPM
  • neutrophil: 18 nTPM
  • intermediate monocyte: 14 nTPM
  • NK-cell: 13 nTPM
  • T-reg: 13 nTPM
  • plasmacytoid DC: 13 nTPM

Brain region

  • cerebellum: 37 nTPM
  • choroid plexus: 36 nTPM
  • medulla oblongata: 36 nTPM
  • thalamus: 33 nTPM
  • white matter: 32 nTPM
  • hypothalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX5.

Disease | AllUniProt

Conditions STX5 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2AA (CDG2AA) MIM:620454

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.84
gnomAD missense Z
0.4
DepMap mean gene effect
-1.48
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX5 as an antibody target. Whether an autoantibody or antibody against STX5 could matter depends on whether native STX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis.

Canonical record: https://seroatlas.com/gene/STX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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