Seroatlas · Human Serome Atlas

COG6

Conserved oligomeric Golgi complex subunit 6

Also known as: COD2, COG6_HUMAN, KIAA1134

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2V7
Gene
COG6
Ensembl
ENSG00000133103
Chromosome
13
Canonical length
657 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q9Y2V7|COG6
     1  MAEGSGEVVA VSATGAANGL NNGAGGTSAT TCNPLSRKLH KILETRLDND KEMLEALKAL
    61  STFFVENSLR TRRNLRGDIE RKSLAINEEF VSIFKEVKEE LESISEDVQA MSNCCQDMTS
   121  RLQAAKEQTQ DLIVKTTKLQ SESQKLEIRA QVADAFLSKF QLTSDEMSLL RGTREGPITE
   181  DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRTLTQE
   241  SCDVSPVLTQ AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH
   301  SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTTQGVEE NIQEVVGHIT EGVCRPLKVR
   361  IEQVIVAEPG AVLLYKISNL LKFYHHTISG IVGNSATALL TTIEEMHLLS KKIFFNSLSL
   421  HASKLMDKVE LPPPDLGPSS ALNQTLMLLR EVLASHDSSV VPLDARQADF VQVLSCVLDP
   481  LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ
   541  ASYVLTRVGL SYIYNTVQQH KPEQGSLANM PNLDSVTLKA AMVQFDRYLS APDNLLIPQL
   601  NFLLSATVKE QIVKQSTELV CRAYGEVYAA VMNPINEYKD PENILHRSPQ QVQTLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 18 nTPM
  • parathyroid gland: 17 nTPM
  • testis: 15 nTPM
  • heart muscle: 15 nTPM
  • thyroid gland: 13 nTPM
  • placenta: 13 nTPM

Single-cell type

  • somatotrophs: 254 nCPM
  • lactotrophs: 245 nCPM
  • thyrotrophs: 182 nCPM
  • corticotrophs: 170 nCPM
  • choroid plexus epithelial cells: 155 nCPM
  • gonadotrophs: 145 nCPM

Immune cell

  • NK-cell: 7.1 nTPM
  • MAIT T-cell: 6.6 nTPM
  • T-reg: 6.5 nTPM
  • naive CD8 T-cell: 5.4 nTPM
  • memory CD8 T-cell: 5.3 nTPM
  • intermediate monocyte: 5 nTPM

Brain region

  • white matter: 26 nTPM
  • cerebral cortex: 26 nTPM
  • cerebellum: 24 nTPM
  • choroid plexus: 24 nTPM
  • basal ganglia: 21 nTPM
  • pons: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG6.

Disease | AllUniProt

Conditions COG6 is implicated in, by any mechanism.

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 452 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • COG6-congenital disorder of glycosylation
  • Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
  • COG6-related disorder
  • Inborn genetic diseases
  • Hypohidrosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
-0.4
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Conserved oligomeric Golgi complex subunit 6
  • Conserved oligomeric complex COG6, N-terminal
  • Conserved Oligomeric Golgi complex subunit 6, C-terminal
  • Conserved oligomeric complex COG6, N-terminal
  • Conserved Oligomeric Golgi complex subunit 6, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG6 as an antibody target. Whether an autoantibody or antibody against COG6 could matter depends on whether native COG6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COG6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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