Seroatlas · Human Serome Atlas

STX3

Syntaxin-3

Also known as: STX3_HUMAN, STX3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13277
Gene
STX3
Ensembl
ENSG00000166900
Chromosome
11
Canonical length
289 aa
Protein class
Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nuclear membrane,Vesicles

OverviewNCBI Gene

The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q13277|STX3
     1  MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY
    61  SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH
   121  SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG
   181  IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV
   241  DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
290 nTPM

Expression across tissuesHPA

Tissue

  • retina: 290 nTPM
  • bone marrow: 56 nTPM
  • duodenum: 56 nTPM
  • kidney: 55 nTPM
  • rectum: 53 nTPM
  • colon: 48 nTPM

Single-cell type

  • neutrophils: 755 nCPM
  • rod photoreceptor cells: 321 nCPM
  • retinal bipolar cells: 301 nCPM
  • mast cells: 292 nCPM
  • neutrophil progenitors: 282 nCPM
  • cone photoreceptor cells: 251 nCPM

Immune cell

  • eosinophil: 74 nTPM
  • neutrophil: 61 nTPM
  • basophil: 43 nTPM
  • myeloid DC: 7.1 nTPM
  • classical monocyte: 6.3 nTPM
  • memory CD4 T-cell: 3.3 nTPM

Brain region

  • cerebellum: 37 nTPM
  • cerebral cortex: 31 nTPM
  • pons: 28 nTPM
  • white matter: 26 nTPM
  • thalamus: 26 nTPM
  • choroid plexus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX3.

Disease | AllUniProt

Conditions STX3 is implicated in, by any mechanism.

  • Retinal dystrophy and microvillus inclusion disease (RDMVID) MIM:619446
  • Diarrhea 12, with microvillus atrophy (DIAR12) MIM:619445

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 238 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Retinal dystrophy and microvillus inclusion disease
  • Diarrhea 12, with microvillus atrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.04
gnomAD missense Z
-0.01
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX3 as an antibody target. Whether an autoantibody or antibody against STX3 could matter depends on whether native STX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX3 is annotated at the cell surface, where native STX3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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