Seroatlas · Human Serome Atlas

STX1A

Syntaxin-1A

Also known as: HPC-1, p35-1, STX1, STX1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16623
Gene
STX1A
Ensembl
ENSG00000106089
Chromosome
7
Canonical length
288 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nuclear membrane,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q16623|STX1A
     1  MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA
    61  ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH
   121  STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG
   181  IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA
   241  VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
170 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 170 nTPM
  • cerebellum: 110 nTPM
  • pituitary gland: 94 nTPM
  • amygdala: 86 nTPM
  • hippocampal formation: 69 nTPM
  • hypothalamus: 25 nTPM

Single-cell type

  • pancreatic islet cells: 94 nCPM
  • platelets: 93 nCPM
  • brain excitatory neurons: 48 nCPM
  • neuroendocrine cells: 44 nCPM
  • lactotrophs: 38 nCPM
  • somatotrophs: 34 nCPM

Immune cell

  • total PBMC: 0.7 nTPM
  • gdT-cell: 0.6 nTPM
  • T-reg: 0.6 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 137 nTPM
  • basal ganglia: 105 nTPM
  • white matter: 92 nTPM
  • hippocampal formation: 74 nTPM
  • amygdala: 69 nTPM
  • cerebellum: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX1A.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.4
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX1A as an antibody target. Whether an autoantibody or antibody against STX1A could matter depends on whether native STX1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX1A is annotated at the cell surface, where native STX1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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