Seroatlas · Human Serome Atlas

STX4

Syntaxin-4

Also known as: p35-2, STX4_HUMAN, STX4A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12846
Gene: STX4
Ensembl: ENSG00000103496
Chromosome: 16
Canonical length: 297 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Implicated in autosomal recessive nonsyndromic deafness. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q12846|STX4
     1  MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ TIVKLGNKVQ
    61  ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ LKAIEPQKEE ADENYNSVNT
   121  RMRKTQHGVL SQQFVELINK CNSMQSEYRE KNVERIRRQL KITNAGMVSD EELEQMLDSG
   181  QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR
   241  IEKNILSSAD YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
adrenal gland: 46 nTPM
skin: 45 nTPM
spleen: 45 nTPM
spinal cord: 43 nTPM
heart muscle: 41 nTPM

Single-cell type

cdc: 96 nCPM
macrophages: 84 nCPM
monocytes: 83 nCPM
hofbauer cells: 81 nCPM
neutrophils: 77 nCPM
esophageal suprabasal cells: 74 nCPM

Immune cell

eosinophil: 27 nTPM
NK-cell: 25 nTPM
intermediate monocyte: 24 nTPM
neutrophil: 23 nTPM
non-classical monocyte: 22 nTPM
classical monocyte: 22 nTPM

Brain region

white matter: 33 nTPM
medulla oblongata: 33 nTPM
hypothalamus: 32 nTPM
pons: 31 nTPM
cerebellum: 31 nTPM
thalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX4.

Disease | AllUniProt

Conditions STX4 is implicated in, by any mechanism.

Deafness, autosomal recessive, 123 (DFNB123) MIM:620745

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Sensorineural hearing loss disorder
Hearing loss, autosomal recessive 123

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SNAP receptor activity
SNARE binding
sphingomyelin phosphodiesterase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX4 as an antibody target. Whether an autoantibody or antibody against STX4 could matter depends on whether native STX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX4 is annotated at the cell surface, where native STX4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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