Seroatlas · Human Serome Atlas

STX7

Syntaxin-7

Also known as: STX7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15400
Gene
STX7
Ensembl
ENSG00000079950
Chromosome
6
Canonical length
261 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Lysosomes

OverviewNCBI Gene

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>O15400|STX7
     1  MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ QLQQKQQYTN
    61  QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS LTNFQKVQRQ AAEREKEFVA
   121  RVRASSRVSG SFPEDSSKER NLVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA
   181  DIMDINEIFK DLGMMIHEQG DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI
   241  IILILVIGVA IISLIIWGLN H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 71 nTPM
  • tonsil: 67 nTPM
  • kidney: 48 nTPM
  • spleen: 43 nTPM
  • placenta: 40 nTPM
  • appendix: 39 nTPM

Single-cell type

  • microglia: 443 nCPM
  • neutrophils: 387 nCPM
  • hofbauer cells: 365 nCPM
  • melanocytes: 364 nCPM
  • b-cells: 318 nCPM
  • platelets: 285 nCPM

Immune cell

  • naive B-cell: 107 nTPM
  • memory B-cell: 86 nTPM
  • neutrophil: 84 nTPM
  • plasmacytoid DC: 74 nTPM
  • non-classical monocyte: 62 nTPM
  • myeloid DC: 62 nTPM

Brain region

  • white matter: 67 nTPM
  • medulla oblongata: 56 nTPM
  • midbrain: 53 nTPM
  • spinal cord: 50 nTPM
  • hypothalamus: 50 nTPM
  • cerebral cortex: 50 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX7.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.81
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX7 as an antibody target. Whether an autoantibody or antibody against STX7 could matter depends on whether native STX7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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