Seroatlas · Human Serome Atlas

RASSF7

Ras association domain-containing protein 7

Also known as: C11orf13, CFAP88, FAP88, HRAS1, HRC1, RASF7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02833
Gene: RASSF7
Ensembl: ENSG00000099849
Chromosome: 11
Canonical length: 373 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

Predicted to be involved in apoptotic process and signal transduction. Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q02833|RASSF7
     1  MLLGLAAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV QRLREKERQL
    61  LPQECPVGAQ ATCGQFASDV QFVLRRTGPS LAGRPSSDSC PPPERCLIRA SLPVKPRAAL
   121  GCEPRKTLTP EPAPSLSRPG PAAPVTPTPG CCTDLRGLEL RVQRNAEELG HEAFWEQELR
   181  REQAREREGQ ARLQALSAAT AEHAARLQAL DAQARALEAE LQLAAEAPGP PSPMASATER
   241  LHQDLAVQER QSAEVQGSLA LVSRALEAAE RALQAQAQEL EELNRELRQC NLQQFIQQTG
   301  AALPPPPRPD RGPPGTQGPL PPAREESLLG APSESHAGAQ PRPRGGPHDA ELLEVAAAPA
   361  PEWCPLAAQP QAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

kidney: 122 nTPM
liver: 90 nTPM
pancreas: 65 nTPM
cerebellum: 64 nTPM
stomach: 62 nTPM
skin: 52 nTPM

Single-cell type

renal collecting duct principal cells: 55 nCPM
podocytes: 46 nCPM
loop of henle epithelial cells: 45 nCPM
renal connecting tubule cells: 38 nCPM
proximal tubule cells: 37 nCPM
papillary tip epithelial cells: 37 nCPM

Immune cell

eosinophil: 23 nTPM
T-reg: 22 nTPM
plasmacytoid DC: 19 nTPM
memory CD4 T-cell: 18 nTPM
gdT-cell: 18 nTPM
MAIT T-cell: 16 nTPM

Brain region

cerebellum: 13 nTPM
pons: 13 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
medulla oblongata: 8 nTPM
hippocampal formation: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -1.57
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

centriolar satellite

Protein domainsUniProt · Pfam · InterPro

Ras-associating domain
Ubiquitin-like domain superfamily
N-terminal RASSF family
Ras association (RalGDS/AF-6) domain
Ras association domain-containing protein 7, RA domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF7 as an antibody target. Whether an autoantibody or antibody against RASSF7 could matter depends on whether native RASSF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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