Seroatlas · Human Serome Atlas

VAMP5

Vesicle-associated membrane protein 5

Also known as: VAMP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95183
Gene: VAMP5
Ensembl: ENSG00000168899
Chromosome: 2
Canonical length: 116 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>O95183|VAMP5
     1  MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST FNKTTQNLAQ
    61  KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS SAPRTQDAGI ASGPGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAMP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 204 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 204 nTPM
tongue: 186 nTPM
lung: 136 nTPM
adipose tissue: 134 nTPM
breast: 121 nTPM
adrenal gland: 120 nTPM

Single-cell type

kupffer cells: 465 nCPM
melanocytes: 304 nCPM
vascular endothelial cells: 291 nCPM
decidual stromal cells: 246 nCPM
hepatocytes: 232 nCPM
lymphatic endothelial cells: 183 nCPM

Immune cell

intermediate monocyte: 505 nTPM
non-classical monocyte: 427 nTPM
total PBMC: 283 nTPM
T-reg: 250 nTPM
classical monocyte: 223 nTPM
gdT-cell: 181 nTPM

Brain region

medulla oblongata: 47 nTPM
thalamus: 45 nTPM
hypothalamus: 41 nTPM
spinal cord: 36 nTPM
basal ganglia: 36 nTPM
pons: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0.01
gnomAD missense Z: 0.08
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Synaptobrevin-like
v-SNARE, coiled-coil homology domain
Synaptobrevin
Vesicle-associated membrane protein 5
VAMP5, SNARE motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAMP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAMP5 as an antibody target. Whether an autoantibody or antibody against VAMP5 could matter depends on whether native VAMP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAMP5 is annotated at the cell surface, where native VAMP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VAMP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...