Seroatlas · Human Serome Atlas

STX12

Syntaxin-12

Also known as: STX12_HUMAN, STX13, STX14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y82
Gene: STX12
Ensembl: ENSG00000117758
Chromosome: 1
Canonical length: 276 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; cholesterol efflux; and protein stabilization. Located in several cellular components, including BLOC-1 complex; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q86Y82|STX12
     1  MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL GTKQDSSKLQ
    61  ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR LQKERLMNDF SAALNNFQAV
   121  QRRVSEKEKE SIARARAGSR LSAEERQREE QLVSFDSHEE WNQMQSQEDE VAITEQDLEL
   181  IKERETAIRQ LEADILDVNQ IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA
   241  AYYQKKSRKK MCILVLVLSV IILILGLIIW LVYKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 89 nTPM
stomach: 62 nTPM
adipose tissue: 60 nTPM
epididymis: 59 nTPM
spinal cord: 54 nTPM
midbrain: 51 nTPM

Single-cell type

parietal cells: 438 nCPM
esophageal apical cells: 387 nCPM
epididymal basal cells: 381 nCPM
epididymal principal cells: 351 nCPM
suprabasal keratinocytes: 267 nCPM
alveolar cells type 1: 257 nCPM

Immune cell

non-classical monocyte: 41 nTPM
intermediate monocyte: 40 nTPM
classical monocyte: 36 nTPM
myeloid DC: 25 nTPM
basophil: 25 nTPM
total PBMC: 17 nTPM

Brain region

midbrain: 77 nTPM
white matter: 75 nTPM
pons: 74 nTPM
medulla oblongata: 71 nTPM
spinal cord: 70 nTPM
hypothalamus: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.96
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX12 as an antibody target. Whether an autoantibody or antibody against STX12 could matter depends on whether native STX12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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