Seroatlas · Human Serome Atlas

EXOC4

Exocyst complex component 4

Also known as: EXOC4_HUMAN, KIAA1699, MGC27170, SEC8, SEC8L1, Sec8p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A65
Gene: EXOC4
Ensembl: ENSG00000131558
Chromosome: 7
Canonical length: 974 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

974 residues, UniProt reviewed canonical sequence.

>Q96A65|EXOC4
     1  MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA YEKCDRDLDE
    61  LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC KMLLHCKRDE LRKLWIEGIE
   121  HKHVLNLLDE IENIKQVPQK LEQCMASKHY LSATDMLVSA VESLEGPLLQ VEGLSDLRLE
   181  LHSKKMNLHL VLIDELHRHL YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK
   241  FLDTSHYSTA GSSSVREINL QDIKEDLELD PEENSTLFMG ILIKGLAKLK KIPETVKAII
   301  ERLEQELKQI VKRSTTQVAD SGYQRGENVT VENQPRLLLE LLELLFDKFN AVAAAHSVVL
   361  GYLQDTVVTP LTQQEDIKLY DMADVWVKIQ DVLQMLLTEY LDMKNTRTAS EPSAQLSYAS
   421  TGREFAAFFA KKKPQRPKNS LFKFESSSHA ISMSAYLREQ RRELYSRSGE LQGGPDDNLI
   481  EGGGTKFVCK PGARNITVIF HPLLRFIQEI EHALGLGPAK QCPLREFLTV YIKNIFLNQV
   541  LAEINKEIEG VTKTSDPLKI LANADTMKVL GVQRPLLQST IIVEKTVQDL LNLMHDLSAY
   601  SDQFLNMVCV KLQEYKDTCT AAYRGIVQSE EKLVISASWA KDDDISRLLK SLPNWMNMAQ
   661  PKQLRPKREE EEDFIRAAFG KESEVLIGNL GDKLIPPQDI LRDVSDLKAL ANMHESLEWL
   721  ASRTKSAFSN LSTSQMLSPA QDSHTNTDLP PVSEQIMQTL SELAKSFQDM ADRCLLVLHL
   781  EVRVHCFHYL IPLAKEGNYA IVANVESMDY DPLVVKLNKD ISAIEEAMSA SLQQHKFQYI
   841  FEGLGHLISC ILINGAQYFR RISESGIKKM CRNIFVLQQN LTNITMSREA DLDFARQYYE
   901  MLYNTADELL NLVVDQGVKY TELEYIHALT LLHRSQTGVG ELTTQNTRLQ RLKEIICEQA
   961  AIKQATKDKK ITTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 64 nTPM
retina: 49 nTPM
tongue: 36 nTPM
ovary: 28 nTPM
thymus: 26 nTPM
pancreas: 26 nTPM

Single-cell type

rod photoreceptor cells: 2,893 nCPM
myonuclei: 1,161 nCPM
cone photoreceptor cells: 1,039 nCPM
sertoli cells: 1,028 nCPM
choroid plexus epithelial cells: 1,016 nCPM
neutrophil progenitors: 781 nCPM

Immune cell

NK-cell: 20 nTPM
myeloid DC: 16 nTPM
intermediate monocyte: 13 nTPM
T-reg: 13 nTPM
classical monocyte: 12 nTPM
memory CD8 T-cell: 12 nTPM

Brain region

choroid plexus: 41 nTPM
cerebral cortex: 33 nTPM
midbrain: 33 nTPM
white matter: 33 nTPM
hippocampal formation: 32 nTPM
pons: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOC4.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 179 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Meckel-Gruber syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

PDZ domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Exocyst complex component Sec8, N-terminal
Exocyst complex component Sec8/EXOC4
Exocyst complex component Sec8, middle helical bundle
Exocyst complex component Sec8 N-terminal
Exocyst complex component Sec8 C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC4 as an antibody target. Whether an autoantibody or antibody against EXOC4 could matter depends on whether native EXOC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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