Seroatlas · Human Serome Atlas

SKA1

SKA complex subunit 1

Also known as: C18orf24, MGC10200, SKA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BD8
Gene
SKA1
Ensembl
ENSG00000154839
Chromosome
18
Canonical length
255 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Primary cilium,Centriolar satellite,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables microtubule binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; negative regulation of mitotic spindle assembly checkpoint signaling; and positive regulation of microtubule polymerization. Located in several cellular components, including intercellular bridge; kinetochore; and microtubule cytoskeleton. Part of SKA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q96BD8|SKA1
     1  MASSDLEQLC SHVNEKIGNI KKTLSLRNCG QEPTLKTVLN KIGDEIIVIN ELLNKLELEI
    61  QYQEQTNNSL KELCESLEED YKDIEHLKEN VPSHLPQVTV TQSCVKGSDL DPEEPIKVEE
   121  PEPVKKPPKE QRSIKEMPFI TCDEFNGVPS YMKSRLTYNQ INDVIKEINK AVISKYKILH
   181  QPKKSMNSVT RNLYHRFIDE ETKDTKGRYF IVEADIKEFT TLKADKKFHV LLNILRHCRR
   241  LSEVRGGGLT RYVIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 11 nTPM
  • lymph node: 4.5 nTPM
  • tonsil: 4.5 nTPM
  • testis: 4.1 nTPM
  • thymus: 3.4 nTPM
  • esophagus: 2.4 nTPM

Single-cell type

  • erythrocyte progenitors: 7 nCPM
  • monocyte progenitors: 4.4 nCPM
  • megakaryocyte progenitors: 3.4 nCPM
  • early spermatids: 1.9 nCPM
  • early primary spermatocytes: 1.6 nCPM
  • plasma cells: 1.4 nCPM

Immune cell

  • basophil: 1 nTPM
  • neutrophil: 0.6 nTPM
  • NK-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • T-reg: 0.4 nTPM

Brain region

  • cerebellum: 9.9 nTPM
  • white matter: 9.7 nTPM
  • thalamus: 7.7 nTPM
  • pons: 7.5 nTPM
  • cerebral cortex: 7.2 nTPM
  • medulla oblongata: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Spindle and kinetochore-associated protein 1
  • SKA1 microtubule binding domain superfamily
  • Spindle and kinetochore-associated protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKA1 as an antibody target. Whether an autoantibody or antibody against SKA1 could matter depends on whether native SKA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SKA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SKA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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