Seroatlas · Human Serome Atlas

STX17

Syntaxin-17

Also known as: FLJ20651, STX17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P56962
Gene
STX17
Ensembl
ENSG00000136874
Chromosome
9
Canonical length
302 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Enables SNAP receptor activity; SNARE binding activity; and protein phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane contact site. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>P56962|STX17
     1  MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK LHEEHINAGR
    61  TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA ATAEFLQLHL ESVEELKKQF
   121  NDEETLLQPP LTRSMTVGGA FHTTEAEASS QSLTQIYALP EIPQDQNAAE SWETLEADLI
   181  ELSQLVTDFS LLVNSQQEKI DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG
   241  GMVGGPIGLL AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK
   301  CS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • liver: 17 nTPM
  • skin: 16 nTPM
  • skeletal muscle: 14 nTPM
  • thyroid gland: 12 nTPM
  • tongue: 12 nTPM
  • salivary gland: 12 nTPM

Single-cell type

  • esophageal apical cells: 157 nCPM
  • gonadotrophs: 127 nCPM
  • pdcs: 121 nCPM
  • adrenal cortex cells: 115 nCPM
  • lactotrophs: 111 nCPM
  • pituicytes/fscs: 107 nCPM

Immune cell

  • basophil: 18 nTPM
  • NK-cell: 14 nTPM
  • MAIT T-cell: 8.9 nTPM
  • naive CD4 T-cell: 8.7 nTPM
  • naive CD8 T-cell: 8.4 nTPM
  • non-classical monocyte: 8.2 nTPM

Brain region

  • cerebellum: 39 nTPM
  • choroid plexus: 34 nTPM
  • white matter: 33 nTPM
  • cerebral cortex: 31 nTPM
  • pons: 30 nTPM
  • hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.59
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX17 as an antibody target. Whether an autoantibody or antibody against STX17 could matter depends on whether native STX17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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