Seroatlas · Human Serome Atlas

VTI1A

Vesicle transport through interaction with t-SNAREs homolog 1A

Also known as: MVti1, Vti1-rp2, VTI1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AJ9
Gene
VTI1A
Ensembl
ENSG00000151532
Chromosome
10
Canonical length
217 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q96AJ9|VTI1A
     1  MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE LLEQMDLEVR
    61  EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR NELLGDDGNS SENQRAHLLD
   121  NTERLERSSR RLEAGYQIAV ETEQIGQEML ENLSHDREKI QRARERLRET DANLGKSSRI
   181  LTGMLRRIIQ NRILLVILGI IVVITILMAI TFSVRRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VTI1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 13 nTPM
  • tonsil: 8.8 nTPM
  • thymus: 8 nTPM
  • lymph node: 7.2 nTPM
  • parathyroid gland: 7 nTPM
  • rectum: 7 nTPM

Single-cell type

  • podocytes: 3,175 nCPM
  • neutrophils: 719 nCPM
  • neutrophil progenitors: 613 nCPM
  • choroid plexus epithelial cells: 494 nCPM
  • microglia: 453 nCPM
  • sertoli cells: 448 nCPM

Immune cell

  • neutrophil: 12 nTPM
  • eosinophil: 9.7 nTPM
  • intermediate monocyte: 9.3 nTPM
  • basophil: 9.2 nTPM
  • non-classical monocyte: 8.8 nTPM
  • T-reg: 7.2 nTPM

Brain region

  • hippocampal formation: 30 nTPM
  • cerebral cortex: 29 nTPM
  • white matter: 29 nTPM
  • thalamus: 28 nTPM
  • midbrain: 28 nTPM
  • pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VTI1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VTI1A as an antibody target. Whether an autoantibody or antibody against VTI1A could matter depends on whether native VTI1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VTI1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VTI1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VTI1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...