SEC61B
Protein transport protein Sec61 subunit beta
Also known as: SC61B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P60468
- Gene
- SEC61B
- Ensembl
- ENSG00000106803
- Chromosome
- 9
- Canonical length
- 96 aa
- Protein class
- Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
96 residues, UniProt reviewed canonical sequence.
>P60468|SEC61B
1 MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA GTGGMWRFYT
61 EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC61B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 523 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 523 nTPM
- liver: 436 nTPM
- salivary gland: 327 nTPM
- epididymis: 245 nTPM
- bone marrow: 241 nTPM
- adrenal gland: 230 nTPM
Single-cell type
- epididymal principal cells: 1,472 nCPM
- plasma cells: 1,331 nCPM
- pdcs: 1,285 nCPM
- esophageal apical cells: 1,008 nCPM
- hepatocytes: 979 nCPM
- esophageal suprabasal cells: 946 nCPM
Immune cell
- plasmacytoid DC: 1,667 nTPM
- basophil: 879 nTPM
- total PBMC: 526 nTPM
- myeloid DC: 482 nTPM
- MAIT T-cell: 482 nTPM
- classical monocyte: 462 nTPM
Brain region
- white matter: 61 nTPM
- hypothalamus: 60 nTPM
- spinal cord: 50 nTPM
- medulla oblongata: 49 nTPM
- choroid plexus: 47 nTPM
- cerebellum: 45 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.03
- DepMap mean gene effect
- -0.41
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- ERAD pathway
- post-translational protein targeting to membrane, translocation
- retrograde protein transport, ER to cytosol
- SRP-dependent cotranslational protein targeting to membrane, translocation
Molecular functions
- epidermal growth factor binding
- guanyl-nucleotide exchange factor activity
- ribosome binding
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein transport protein SecG/Sec61-beta/Sbh
- Protein transport Sec61-beta/Sbh
- Sec61beta family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SEC61B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC61B as an antibody target. Whether an autoantibody or antibody against SEC61B could matter depends on whether native SEC61B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC61B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC61B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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