SERP2
Stress-associated endoplasmic reticulum protein 2
Also known as: bA269C23.1, C13orf21, SERP2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N6R1
- Gene
- SERP2
- Ensembl
- ENSG00000151778
- Chromosome
- 13
- Canonical length
- 65 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
65 residues, UniProt reviewed canonical sequence.
>Q8N6R1|SERP2
1 MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSAIFQIIQS
61 IRMGMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SERP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 94 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 94 nTPM
- basal ganglia: 82 nTPM
- amygdala: 76 nTPM
- hippocampal formation: 62 nTPM
- hypothalamus: 51 nTPM
- midbrain: 46 nTPM
Single-cell type
- early spermatids: 800 nCPM
- late spermatids: 315 nCPM
- late primary spermatocytes: 191 nCPM
- undifferentiated spermatogonia: 57 nCPM
- brain inhibitory neurons: 44 nCPM
- adrenal medulla cells: 43 nCPM
Immune cell
- basophil: 2.6 nTPM
- NK-cell: 0.6 nTPM
- MAIT T-cell: 0.1 nTPM
- total PBMC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 54 nTPM
- basal ganglia: 47 nTPM
- white matter: 41 nTPM
- hypothalamus: 39 nTPM
- hippocampal formation: 39 nTPM
- midbrain: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.83
- gnomAD pLI
- 0.67
- gnomAD missense Z
- 0.92
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SERP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SERP2 as an antibody target. Whether an autoantibody or antibody against SERP2 could matter depends on whether native SERP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SERP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SERP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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