Seroatlas · Human Serome Atlas

RPN2

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Also known as: RIBIIR, RPN-II, RPN2_HUMAN, RPNII, SWP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04844
Gene
RPN2
Ensembl
ENSG00000118705
Chromosome
20
Canonical length
631 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>P04844|RPN2
     1  MAPPGSSTVF LLALTIIAST WALTPTHYLT KHDVERLKAS LDRPFTNLES AFYSIVGLSS
    61  LGAQVPDAKK ACTYIRSNLD PSNVDSLFYA AQASQALSGC EISISNETKD LLLAAVSEDS
   121  SVTQIYHAVA ALSGFGLPLA SQEALSALTA RLSKEETVLA TVQALQTASH LSQQADLRSI
   181  VEEIEDLVAR LDELGGVYLQ FEEGLETTAL FVAATYKLMD HVGTEPSIKE DQVIQLMNAI
   241  FSKKNFESLS EAFSVASAAA VLSHNRYHVP VVVVPEGSAS DTHEQAILRL QVTNVLSQPL
   301  TQATVKLEHA KSVASRATVL QKTSFTPVGD VFELNFMNVK FSSGYYDFLV EVEGDNRYIA
   361  NTVELRVKIS TEVGITNVDL STVDKDQSIA PKTTRVTYPA KAKGTFIADS HQNFALFFQL
   421  VDVNTGAELT PHQTFVRLHN QKTGQEVVFV AEPDNKNVYK FELDTSERKI EFDSASGTYT
   481  LYLIIGDATL KNPILWNVAD VVIKFPEEEA PSTVLSQNLF TPKQEIQHLF REPEKRPPTV
   541  VSNTFTALIL SPLLLLFALW IRIGANVSNF TFAPSTIIFH LGHAAMLGLM YVYWTQLNMF
   601  QTLKYLAILG SVTFLAGNRM LAQQAVKRTA H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
325 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 325 nTPM
  • placenta: 241 nTPM
  • choroid plexus: 222 nTPM
  • thyroid gland: 216 nTPM
  • liver: 197 nTPM
  • bone marrow: 170 nTPM

Single-cell type

  • oocytes: 1,128 nCPM
  • extravillous trophoblasts: 859 nCPM
  • syncytiotrophoblasts: 802 nCPM
  • plasma cells: 577 nCPM
  • cytotrophoblasts: 551 nCPM
  • migrating cytotrophoblasts: 520 nCPM

Immune cell

  • total PBMC: 676 nTPM
  • plasmacytoid DC: 591 nTPM
  • myeloid DC: 480 nTPM
  • classical monocyte: 426 nTPM
  • basophil: 424 nTPM
  • MAIT T-cell: 417 nTPM

Brain region

  • choroid plexus: 154 nTPM
  • white matter: 79 nTPM
  • hypothalamus: 69 nTPM
  • thalamus: 68 nTPM
  • medulla oblongata: 64 nTPM
  • spinal cord: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.11
gnomAD missense Z
0.01
DepMap mean gene effect
-0.62
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1
  • Ribophorin II, N-terminal domain
  • Ribophorin II, third domain
  • Ribophorin II, second domain
  • Ribophorin II, C-terminal domain
  • Ribophorin II N-terminal domain
  • Ribophorin II third domain
  • Ribophorin II second domain
  • Ribophorin_II, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPN2 as an antibody target. Whether an autoantibody or antibody against RPN2 could matter depends on whether native RPN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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